Phenotypes associated with this allele

• Allele Symbol: Foxk1^tm1.1Sven
• Allele Name: targeted mutation 1.1, Sven Enerback
• Allele ID: MGI:6356326
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Foxk1^tm1.1Sven/Foxk1^tm1.1Sven Foxk2^tm1.1Sven/Foxk2^tm1.1Sven Tg(Ckmm-cre)5Khn/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB	MGI:7861806

Genotype
MGI:7861806

cn1

• Allelic Composition: Foxk1^tm1.1Sven/Foxk1^tm1.1Sven; Foxk2^tm1.1Sven/Foxk2^tm1.1Sven; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired exercise endurance ( J:273343 )

♂ • 8-month-old male mice show a significantly lower average run time on a treadmill than wild-type controls

homeostasis/metabolism

impaired exercise endurance ( J:273343 )

♂ • 8-month-old male mice show a significantly lower average run time on a treadmill than wild-type controls

decreased enzyme/coenzyme level ( J:273343 )

♂ • mice show a significant reduction in mRNA levels of Ldha (lactate dehydrogenase A) and Pkm (pyruvate kinase muscle-1, PKM-M1), which are target genes of FOXK1 and FOXK2, in soleus and extensor digitorium longus (EDL) muscle

decreased lactate dehydrogenase level ( J:273343 )

♂ • mice show a significant reduction in mRNA levels of Ldha (lactate dehydrogenase A) in soleus and EDL muscle