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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxk2tm1.1Sven
targeted mutation 1.1, Sven Enerback
MGI:6356327
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Foxk2tm1.1Sven/Foxk2tm1.1Sven B6.129P2-Foxk2tm1.1Sven MGI:7861802
cn2
 		Foxk1tm1.1Sven/Foxk1tm1.1Sven
Foxk2tm1.1Sven/Foxk2tm1.1Sven
Tg(Ckmm-cre)5Khn/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB MGI:7861806


Genotype
MGI:7861802
hm1
Allelic
Composition		 Foxk2tm1.1Sven/Foxk2tm1.1Sven
Genetic
Background		 B6.129P2-Foxk2tm1.1Sven
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxk2tm1.1Sven mutation (0 available); any Foxk2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
decreased adipocyte glucose uptake ( J:273343 )
• MEF-derived adipocytes from homozygous mice transduced with cre show significantly lower 2-deoxyglucose uptake than adipocytes from wild-type controls with or without 100 nM insulin

cellular
decreased adipocyte glucose uptake ( J:273343 )
• MEF-derived adipocytes from homozygous mice transduced with cre show significantly lower 2-deoxyglucose uptake than adipocytes from wild-type controls with or without 100 nM insulin




Genotype
MGI:7861806
cn2
Allelic
Composition		 Foxk1tm1.1Sven/Foxk1tm1.1Sven
Foxk2tm1.1Sven/Foxk2tm1.1Sven
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxk1tm1.1Sven mutation (0 available); any Foxk1 mutation (30 available)
Foxk2tm1.1Sven mutation (0 available); any Foxk2 mutation (21 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired exercise endurance ( J:273343 )
• 8-month-old male mice show a significantly lower average run time on a treadmill than wild-type controls

homeostasis/metabolism
impaired exercise endurance ( J:273343 )
• 8-month-old male mice show a significantly lower average run time on a treadmill than wild-type controls
decreased enzyme/coenzyme level ( J:273343 )
• mice show a significant reduction in mRNA levels of Ldha (lactate dehydrogenase A) and Pkm (pyruvate kinase muscle-1, PKM-M1), which are target genes of FOXK1 and FOXK2, in soleus and extensor digitorium longus (EDL) muscle
decreased lactate dehydrogenase level ( J:273343 )
• mice show a significant reduction in mRNA levels of Ldha (lactate dehydrogenase A) in soleus and EDL muscle




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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory