Analysis Tools
growth/size/body
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• at 19-31 weeks of age, mice exhibit a significantly lower body weight than wild-type controls
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homeostasis/metabolism
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• after 10 weeks of high-fat diet (HFD) feeding, fasted 6-mo-old males show significantly increased plasma insulin concentrations during intraperitoneal glucose tolerance testing
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• after 4 h of fasting, male mice show ~25% lower blood lactate levels than wild-type controls
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• after 10 weeks of high-fat diet (HFD) feeding, fasted 6-mo-old males show significantly increased glucose concentrations during intraperitoneal glucose tolerance testing
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cellular
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• after i.p. with 2-[1,2-3H(N)]-deoxy-d-glucose, 6-mo-old males show decreased glucose uptake in several tissues, including kidney, lung and muscle
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• after i.p. with 2-[1,2-3H(N)]-deoxy-d-glucose, 6-mo-old males show decreased glucose uptake in the soleus and gastrocnemius muscles
• however, histology and fiber composition of soleus muscle appears normal
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muscle
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• after i.p. with 2-[1,2-3H(N)]-deoxy-d-glucose, 6-mo-old males show decreased glucose uptake in the soleus and gastrocnemius muscles
• however, histology and fiber composition of soleus muscle appears normal
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