Phenotypes associated with this allele

• Allele Symbol: Slc2a6^em1Kusu
• Allele Name: endonuclease-mediated mutation 1, Hiroyuki Kusuhara
• Allele ID: MGI:6356342
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc2a6^em1Kusu/Slc2a6^em1Kusu	involves: C57BL/6JCrlj	MGI:6714210

Genotype
MGI:6714210

hm1

• Allelic Composition: Slc2a6^em1Kusu/Slc2a6^em1Kusu
• Genetic Background: involves: C57BL/6JCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:270487 )

• the enhanced lactate secretion by LPS seen in control peritoneal macrophages is weakened, indicating a defect in glycolysis activation in inflammatory macrophages

• however, cytokine expression in macrophages and glucose uptake in peritoneal macrophages are unaffected

increased circulating tumor necrosis factor level ( J:270487 )

• mice show an increase in plasma TNF-alpha levels in response to LPS

increased susceptibility to endotoxin shock ( J:270487 )

• mice exhibit a low resistance to LPS-induced shock compared to controls

hematopoietic system

abnormal macrophage physiology ( J:270487 )

• the enhanced lactate secretion by LPS seen in control peritoneal macrophages is weakened, indicating a defect in glycolysis activation in inflammatory macrophages

• however, cytokine expression in macrophages and glucose uptake in peritoneal macrophages are unaffected

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:270487 )

• mice show an increase in plasma TNF-alpha levels in response to LPS