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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sun5em1Wli
endonuclease-mediated mutation 1, Wei Li
MGI:6356352
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sun5em1Wli/Sun5em1Wli involves: C57BL/6J * DBA/2 MGI:6358746
ht2
 		Sun5em1Wli/Sun5+ involves: C57BL/6J * DBA/2 MGI:6358747


Genotype
MGI:6358746
hm1
Allelic
Composition		 Sun5em1Wli/Sun5em1Wli
Genetic
Background		 involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun5em1Wli mutation (0 available); any Sun5 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:247612 )
N
• normal testes weight
teratozoospermia ( J:247612 )
• most of motile spermatozoa in caudal epididymis belong to slow- or medium-moving classes
• significantly reduced percentage of motile spermatozoa in caudal epididymis
• normal sperm concentration in caudal epididymis
abnormal sperm head morphology ( J:247612 )
• majority of heads are round
• the few normal shaped heads are separated from flagella
globozoospermia ( J:247612 )
• majority of heads are round and are devoid of chromatin
absent sperm head ( J:247612 )
• very low ratio of sperm with head versus tails only in caput, corpus and cauda epididymis
abnormal spermiation ( J:247612 )
• spermatids misoriented (heads towards lumen) in stage VII-VIII seminiferous tubules

cellular
teratozoospermia ( J:247612 )
• significantly reduced percentage of motile spermatozoa in caudal epididymis
• most of motile spermatozoa in caudal epididymis belong to slow- or medium-moving classes
• normal sperm concentration in caudal epididymis
abnormal sperm head morphology ( J:247612 )
• majority of heads are round
• the few normal shaped heads are separated from flagella
globozoospermia ( J:247612 )
• majority of heads are round and are devoid of chromatin
absent sperm head ( J:247612 )
• very low ratio of sperm with head versus tails only in caput, corpus and cauda epididymis

mortality/aging
mortality/aging ( J:247612 )
N
• viable




Genotype
MGI:6358747
ht2
Allelic
Composition		 Sun5em1Wli/Sun5+
Genetic
Background		 involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun5em1Wli mutation (0 available); any Sun5 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:247612 )
N
• viable

reproductive system
reproductive system phenotype ( J:247612 )
N
• normal testes weight
• fertile




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory