Phenotypes associated with this allele

• Allele Symbol: Stk38^em2Flca
• Allele Name: endonuclease-mediated mutation 2, Francis C Luca
• Allele ID: MGI:6356403
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk38^em2Flca/Stk38^em2Flca	C57BL/6-Stk38^em2Flca	MGI:6356902

Genotype
MGI:6356902

hm1

• Allelic Composition: Stk38^em2Flca/Stk38^em2Flca
• Genetic Background: C57BL/6-Stk38^em2Flca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:265036 )

N • young mice exhibit normal ERG and visual placement responses

N • mice exhibit normal distribution of horizontal and bipolar cells as well as Mueller cell proliferation

abnormal retina morphology ( J:265036 )

• opsin is mislocalized to the inner segments, the perinuclear cytoplasm in the outer nuclear layer and the rod synaptic terminals in the outer plexiform layer

abnormal amacrine cell morphology ( J:265036 )

• amacrine cell interneuron organization is disrupted with localization of Pax6+ cells throughout the inner nuclear layer and mitotic calretinin+ cells in both the inner nuclear layer and retinal ganglion layer

abnormal retina inner nuclear layer thickness ( J:265036 )

• reduced by 1 to 3 nuclei in the central retina of adult mice

thin retina outer nuclear layer ( J:265036 )

• reduced by 1 to 3 nuclei in the central retina of adult mice

abnormal eye physiology ( J:265036 )

• increased cellular proliferation in the inner nuclear layer and retinal ganglion layer, likely photoreceptors

• increased amacrine cell proliferation with reduced mature amacrine cell marker expression

increased retina apoptosis ( J:265036 )

• 2- to 3- fold increase of photoreceptor death in the inner nuclear layer

nervous system

abnormal amacrine cell morphology ( J:265036 )

• amacrine cell interneuron organization is disrupted with localization of Pax6+ cells throughout the inner nuclear layer and mitotic calretinin+ cells in both the inner nuclear layer and retinal ganglion layer

cellular

increased retina apoptosis ( J:265036 )

• 2- to 3- fold increase of photoreceptor death in the inner nuclear layer