Analysis Tools
cellular
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• locus is maternally imprinted with no gene expression detectable in mice that have paternally inherited the mutant allele
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endocrine/exocrine glands
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• mice inheriting the allele paternally exhibit impaired glucose-stimulated insulin secretion
• mice with the paternally inherited allele do not show a normal hyperinsulinemic response to Western diet exposure, with persistence of the defect in glucose-stimulated insulin secretion seen on chow diet
• pancreatic beta cells from mice with the paternally inherited allele show a 2-fold increase in insulin secretion with high glucose compared to 7.2-fold increase by wild-type cells
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homeostasis/metabolism
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• mice inheriting the allele paternally exhibit impaired glucose-stimulated insulin secretion
• mice with the paternally inherited allele do not show a normal hyperinsulinemic response to Western diet exposure, with persistence of the defect in glucose-stimulated insulin secretion seen on chow diet
• pancreatic beta cells from mice with the paternally inherited allele show a 2-fold increase in insulin secretion with high glucose compared to 7.2-fold increase by wild-type cells
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• fasting blood glucose progressively increases in mice that inherit the paternal allele during exposure to Western diet
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• progressive deterioration of glucose tolerance is seen over 12 weeks in males with the paternal allele on the Western diet
• however, glucose tolerance is unaffected in chow-fed mice with the paternal allele
• however, no differences in body weight or insulin sensitivity are seen on the Western diet in mice with the paternally inherited allele, suggesting a decline in beta cell function
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