Phenotypes associated with this allele

• Allele Symbol: Rbks^{tm1d(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:6356625
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rbks^tm1d(EUCOMM)Wtsi/Rbks^tm1d(EUCOMM)Wtsi	involves: C57BL/6N * C57BL/6NTac	MGI:6457319

Genotype
MGI:6457319

hm1

• Allelic Composition: Rbks^{tm1d(EUCOMM)Wtsi}/Rbks^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N * C57BL/6NTac
• Cell Lines: EPD0116_3_A10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:236053 )

N • mice show no overt changes in small intestine length or gut morphology

abnormal gastrointestinal motility ( J:236053 )

• whole gut motility is enhanced, as shown by a 32% reduction in whole gut transition time relative to wild type controls

• at 30 min after charcoal gavage, the gastrointestinal transition rate is increased by 33% relative to wild type controls; however, no changes in gastric weight are observed after charcoal gavage

interstinal hyperperistalsis ( J:236053 )

• motility of the small intestine is enhanced as a result of ribose accumulation

abnormal intestine physiology ( J:236053 )

• mice exhibit a significantly increased ribose/ribose-5-phosphate ratio in the small intestine

muscle

interstinal hyperperistalsis ( J:236053 )

• motility of the small intestine is enhanced as a result of ribose accumulation