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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zpld1cwh
circler with hearing
MGI:6356634
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Zpld1cwh/Zpld1cwh B6(129P2)-Zpld1cwh/Kjn MGI:6358185
ht2
Zpld1cwh/Zpld1+ B6(129P2)-Zpld1cwh/Kjn MGI:6358217


Genotype
MGI:6358185
hm1
Allelic
Composition
Zpld1cwh/Zpld1cwh
Genetic
Background
B6(129P2)-Zpld1cwh/Kjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zpld1cwh mutation (1 available); any Zpld1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• the vestibulo-occular reflex is less impaired in cwh homozygotes than in homozygotes for the sprl allele
• although homozygotes are able to swim at the water's surface, they swim in circles
• all homozygotes circle, whereas only approximately half of sprl homozygotes circle and homozygotes for a null allele were not found to circle

hearing/vestibular/ear
N
• normal ABR thresholds and vestibular sensory evoked potentials, normal appearing cochlea and otoconia in both the saccule and utricle, and intact otoconial membranes despite the vestibular dysfunction
• the vestibulo-occular reflex is less impaired in cwh homozygotes than in homozygotes for the sprl allele




Genotype
MGI:6358217
ht2
Allelic
Composition
Zpld1cwh/Zpld1+
Genetic
Background
B6(129P2)-Zpld1cwh/Kjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zpld1cwh mutation (1 available); any Zpld1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• all heterozygotes display reduced vestibuloocular gain, but less severe than in homozygotes, and only 1 in 37 heterozygotes display circling behavior

hearing/vestibular/ear
• all heterozygotes display reduced vestibuloocular gain, but less severe than in homozygotes, and only 1 in 37 heterozygotes display circling behavior





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory