behavior/neurological
• a significant reduction in vestibulo-occular gain is found in homozygotes but not heterozygotes and homozygotes are more severely impaired than are cwh homozygotes
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• approximately half of sprl homozygotes circle whereas all mice homozygous for the cwh allele circle and homozygotes for a null allele were not found to circle
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hearing/vestibular/ear
N |
• normal ABR thresholds and vestibular sensory evoked potentials, normal appearing cochlea and otoconia in both the saccule and utricle, and intact otoconial membranes despite the vestibular dysfunction
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• a significant reduction in vestibulo-occular gain is found in homozygotes but not heterozygotes and homozygotes are more severely impaired than are cwh homozygotes
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