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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zpld1sprl
spiral
MGI:6356635
Summary 2 genotypes


Genotype
MGI:6358216
hm1
Allelic
Composition
Zpld1sprl/Zpld1sprl
Genetic
Background
B6(129S4)-Zpld1sprl/Kjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zpld1sprl mutation (1 available); any Zpld1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• a significant reduction in vestibulo-occular gain is found in homozygotes but not heterozygotes and homozygotes are more severely impaired than are cwh homozygotes
• approximately half of sprl homozygotes circle whereas all mice homozygous for the cwh allele circle and homozygotes for a null allele were not found to circle

hearing/vestibular/ear
N
• normal ABR thresholds and vestibular sensory evoked potentials, normal appearing cochlea and otoconia in both the saccule and utricle, and intact otoconial membranes despite the vestibular dysfunction
• a significant reduction in vestibulo-occular gain is found in homozygotes but not heterozygotes and homozygotes are more severely impaired than are cwh homozygotes




Genotype
MGI:6358226
ht2
Allelic
Composition
Zpld1em1(IMPC)J/Zpld1sprl
Genetic
Background
(C57BL/6NJ-Zpld1em1(IMPC)J/Mmjax x B6(129S4)-Zpld1sprl/Kjn)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zpld1em1(IMPC)J mutation (2 available); any Zpld1 mutation (25 available)
Zpld1sprl mutation (1 available); any Zpld1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• null homozygotes do not display circling and approximately half of sprl homozygotes do display circling, 27% of compound heterozygotes display circling





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory