Phenotypes associated with this allele

• Allele Symbol: Kirrel1^tm1.2Geno
• Allele Name: targeted mutation 1.2, Genoway
• Allele ID: MGI:6356795
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kirrel1^tm1.2Geno/Kirrel1^tm1.2Geno	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:6460374
cx2	Kirrel1^tm1.2Geno/Kirrel1^+ Magi1^tm1Itl/Magi1^tm1Itl	involves: C57BL/6	MGI:6379280

Genotype
MGI:6460374

hm1

• Allelic Composition: Kirrel1^tm1.2Geno/Kirrel1^tm1.2Geno
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:241326 )

• mice die perinatally

renal/urinary system

increased urine protein level ( J:241326 )

• mice are born with nephrotic-range proteinuria

abnormal podocyte foot process morphology ( J:241326 )

• mice exhibit broadened primary processes and shortened secondary foot processes

• mice have misdirected foot processes but, at least at early stages of glomerular maturation, are able to form slit diaphragm-like junctions

abnormal podocyte slit diaphragm morphology ( J:241326 )

• slit diaphragm-like junctions often appear dislocated apically

abnormal renal reabsorption ( J:241326 )

• glomeruli show signs of increased tubular protein uptake with mice showing protein-filled proximal tubular cells

homeostasis/metabolism

increased urine protein level ( J:241326 )

• mice are born with nephrotic-range proteinuria

Genotype
MGI:6379280

cx2

• Allelic Composition: Kirrel1^tm1.2Geno/Kirrel1⁺; Magi1^tm1Itl/Magi1^tm1Itl
• Genetic Background: involves: C57BL/6

normal phenotype

no abnormal phenotype detected ( J:237632 )

• No significant histological changes or proteinuria were detected (0 pf 20 mice)

• did not show glomerular pathological changes (0 pf 20 mice)