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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sepsecsem1(IMPC)Tcp
endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI:6356808
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sepsecsem1(IMPC)Tcp/Sepsecsem1(IMPC)Tcp C57BL/6NCrl-Sepsecsem1(IMPC)Tcp/Cmmr MGI:6493086
ht2
 		Sepsecsem1(IMPC)Tcp/Sepsecs+ C57BL/6NCrl-Sepsecsem1(IMPC)Tcp/Cmmr MGI:6696894


Genotype
MGI:6493086
hm1
Allelic
Composition		 Sepsecsem1(IMPC)Tcp/Sepsecsem1(IMPC)Tcp
Genetic
Background		 C57BL/6NCrl-Sepsecsem1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sepsecsem1(IMPC)Tcp mutation (2 available); any Sepsecs mutation (25 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Sepsecsem1(IMPC)Tcp/Sepsecsem1(IMPC)Tcp mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos exhibit severe developmental delay as small egg cylinders, poorly organized extraembryonic tissues, and failure of gastrulation.

embryo
failure to gastrulate ( J:279207 )
• embryos fail to initiate gastrulation; no Brachyury (T)-positive cells are present at E7.5
embryonic growth retardation ( J:279207 )
• embryos show a severe developmental delay at E7.5
decreased egg cylinder size ( J:279207 )
• a small egg cylinder is observed at E7.5
failure of primitive streak formation ( J:279207 )
• no Brachyury (T)-positive cells are present at E7.5
disorganized extraembryonic tissue ( J:279207 )
• extraembryonic tissues are poorly organized at E7.5

growth/size/body
embryonic growth retardation ( J:279207 )
• embryos show a severe developmental delay at E7.5

mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )
• homozygous embryos are present at E7.5 (14% versus 25%, n=44); no homozygous embryos are recovered at E9.5




Genotype
MGI:6696894
ht2
Allelic
Composition		 Sepsecsem1(IMPC)Tcp/Sepsecs+
Genetic
Background		 C57BL/6NCrl-Sepsecsem1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sepsecsem1(IMPC)Tcp mutation (2 available); any Sepsecs mutation (25 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

homeostasis/metabolism

integument
thick skin ( J:211773 )
IMPC - TCP




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory