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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Amotl1tm1Laho
targeted mutation 1, Lars Holmgren
MGI:6356823
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Amotl1tm1Laho/Amotl1tm1Laho
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Cdh5-cre/ERT2)1Rha/0 		involves: 129X1/SvJ * C57BL/6 MGI:6723729
cn2
 		Amotl1tm1Laho/Amotl1tm1Laho
Tg(Cdh5-cre/ERT2)1Rha/0 		involves: C57BL/6 MGI:6723732
cn3
 		Amotl1tm1Laho/Amotl1tm1Laho
Tg(Cdh5-cre/ERT2)1Rha/0
Tg(MMTV-PyVT)634Mul/0 		involves: C57BL/6 * FVB/N MGI:6723730


Genotype
MGI:6723729
cn1
Allelic
Composition		 Amotl1tm1Laho/Amotl1tm1Laho
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amotl1tm1Laho mutation (0 available); any Amotl1 mutation (56 available)
Gt(ROSA)26Sortm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:253854 )
• pups injected with tamoxifen at P1-P3 show a decreased density of the vessel network covering a smaller area of the retina at P6; the vascular density and number of branching points are significantly lower in the periphery and center of P6 retinas
• however, mice injected with tamoxifen at an adult stage show no alterations in the number of branching points and vascular density in adult retinas
abnormal retina blood vessel morphology ( J:253854 )
• pups injected with tamoxifen at P1-P3 show a small but significant reduction in the number of tip cells per vessel length and abnormal pericyte morphology resulting in decreased pericyte coverage of blood vessels in P6 retinas
• however, the number of filopodia per tip cell is relatively normal at P6
abnormal pericyte morphology ( J:253854 )
• pups injected with tamoxifen at P1-P3 show abnormal pericyte morphology, with mural cells "bulging out" from blood vessels, in P6 retinas

vision/eye
abnormal retina vasculature morphology ( J:253854 )
• pups injected with tamoxifen at P1-P3 show a decreased density of the vessel network covering a smaller area of the retina at P6; the vascular density and number of branching points are significantly lower in the periphery and center of P6 retinas
• however, mice injected with tamoxifen at an adult stage show no alterations in the number of branching points and vascular density in adult retinas
abnormal retina blood vessel morphology ( J:253854 )
• pups injected with tamoxifen at P1-P3 show a small but significant reduction in the number of tip cells per vessel length and abnormal pericyte morphology resulting in decreased pericyte coverage of blood vessels in P6 retinas
• however, the number of filopodia per tip cell is relatively normal at P6




Genotype
MGI:6723732
cn2
Allelic
Composition		 Amotl1tm1Laho/Amotl1tm1Laho
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amotl1tm1Laho mutation (0 available); any Amotl1 mutation (56 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal tumor vascularization ( J:253854 )
• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells exhibit a significant increase in tumor blood vessel diameter relative to control mice
• however, tumor weight of LLC tumors is not significantly altered

neoplasm
abnormal tumor vascularization ( J:253854 )
• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells exhibit a significant increase in tumor blood vessel diameter relative to control mice
• however, tumor weight of LLC tumors is not significantly altered




Genotype
MGI:6723730
cn3
Allelic
Composition		 Amotl1tm1Laho/Amotl1tm1Laho
Tg(Cdh5-cre/ERT2)1Rha/0
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amotl1tm1Laho mutation (0 available); any Amotl1 mutation (56 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (4 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal tumor vascularization ( J:253854 )
• mice injected with tamoxifen show significantly enlarged and dilated infiltrating blood vessels in the mammary tumor area relative to control mice, as determined by vessel diameter
• however, adult retinal vessels from these mice exhibit no changes in vessel diameter

neoplasm
abnormal tumor vascularization ( J:253854 )
• mice injected with tamoxifen show significantly enlarged and dilated infiltrating blood vessels in the mammary tumor area relative to control mice, as determined by vessel diameter
• however, adult retinal vessels from these mice exhibit no changes in vessel diameter
increased tumor latency ( J:253854 )
• mice injected with tamoxifen exhibit a longer lag time until mammary gland tumors are detected relative to control mice
• however, overall tumor progression is not affected




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory