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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim65em2Cya
endonuclease-mediated mutation 2, Cyagen Biosciences
MGI:6356826
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trim65em2Cya/Trim65em2Cya involves: C57BL/6 MGI:6822327


Genotype
MGI:6822327
hm1
Allelic
Composition		 Trim65em2Cya/Trim65em2Cya
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim65em2Cya mutation (0 available); any Trim65 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-beta secretion ( J:240099 )
• following infection with encephalomyocarditis virus (EMCV), induction of IFN-beta mRNA expression in bone marrow derived macrophages (BMDMs) is completely inhibited
• in contrast, following infection with vesicular stomatitis virus (VSV, Indiana strain), IFN-beta mRNA expression in BMDMs is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory