Phenotypes associated with this allele

• Allele Symbol: Trim31^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:6356828
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim31^em1Cya/Trim31^em1Cya	involves: C57BL/6	MGI:6358800

Genotype
MGI:6358800

hm1

• Allelic Composition: Trim31^em1Cya/Trim31^em1Cya
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal colon morphology ( J:243237 )

• longer colon length (compared to wild-type) after dextran sodium sulfate (DSS)-induced colitis

• reduced colonic inflammation and no ulceration (compared to wild-type) after DSS-induced colitis

abnormal digestive system physiology ( J:243237 )

• reduced rectal hemorrhage and better stool consistency score (compared to wild-type) from day 5 after dextran sodium sulfate (DSS)-induced colitis

decreased susceptibility to induced colitis ( J:243237 )

• reduced body weight loss (compared to wild-type) from 4 days after dextran sodium sulfate (DSS)-induced colitis

• reduced rectal hemorrhage and better stool consistency score (compared to wild-type) from day 5 after DSS-induced colitis

• longer colon length (compared to wild-type) after DSS-induced colitis

• reduced colonic inflammation and no ulceration (compared to wild-type) after DSS-induced colitis

immune system

decreased susceptibility to induced colitis ( J:243237 )

• reduced body weight loss (compared to wild-type) from 4 days after dextran sodium sulfate (DSS)-induced colitis

• reduced rectal hemorrhage and better stool consistency score (compared to wild-type) from day 5 after DSS-induced colitis

• longer colon length (compared to wild-type) after DSS-induced colitis

• reduced colonic inflammation and no ulceration (compared to wild-type) after DSS-induced colitis

increased neutrophil cell number ( J:243237 )

• amongst peritoneal exudate cells (PECs) after alum-induced peritonitis

increased Ly6C high monocyte number ( J:243237 )

• amongst peritoneal exudate cells (PECs) after alum-induced peritonitis

abnormal circulating cytokine level ( J:243237 )

• increased serum Il1b levels after lipopolysaccharide (LPS) injection

• normal Il6 and Tnfa levels after lipopolysaccharide (LPS) injection

increased circulating interleukin-1 beta level ( J:243237 )

• after lipopolysaccharide (LPS) injection

hematopoietic system

increased neutrophil cell number ( J:243237 )

• amongst peritoneal exudate cells (PECs) after alum-induced peritonitis

increased Ly6C high monocyte number ( J:243237 )

• amongst peritoneal exudate cells (PECs) after alum-induced peritonitis

homeostasis/metabolism

abnormal circulating cytokine level ( J:243237 )

• increased serum Il1b levels after lipopolysaccharide (LPS) injection

• normal Il6 and Tnfa levels after lipopolysaccharide (LPS) injection

increased circulating interleukin-1 beta level ( J:243237 )

• after lipopolysaccharide (LPS) injection

growth/size/body

abnormal body weight ( J:243237 )

• reduced body weight loss (compared to wild-type) from 4 days after dextran sodium sulfate (DSS)-induced colitis