Phenotypes associated with this allele

• Allele Symbol: Pcgf6^tm1.2Hko
• Allele Name: targeted mutation 1.2, Haruhiko Koseki
• Allele ID: MGI:6357174
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pcgf6^tm1.2Hko/Pcgf6^tm1.2Hko	involves: 129 * C57BL/6	MGI:6363197

Genotype
MGI:6363197

hm1

• Allelic Composition: Pcgf6^tm1.2Hko/Pcgf6^tm1.2Hko
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:258919 )

• homozygotes are not born at the expected Mendelian ratio; lethality is observed as early as the blastocyst stage (E3.5) and continuously detected during post-implantation development

embryo

abnormal rostral-caudal axis patterning ( J:258919 )

• newborn mice show defects in anterior-posterior (A-P) patterning of the axial skeleton

• anterior transformations are accompanied by aberrant repression of Hoxb6 at the eighth pre-vertebra

abnormal preimplantation embryo development ( J:258919 )

embryonic growth retardation ( J:258919 )

• about one third of surviving embryos show growth retardation at E10.5

abnormal pluripotent precursor cell morphology ( J:258919 )

• blastocysts derived from crosses between homozygous or heterozygous males with heterozygous females and grown in culture under ESC inducing conditions fail to generate ES cell-like lines

decreased trophoblast giant cell number ( J:258919 )

• at E11.5, the number of trophoblast giant cells is dramatically reduced

decreased spongiotrophoblast cell number ( J:258919 )

• at E11.5, the number of spongiotrophoblast cells is dramatically reduced

abnormal placenta labyrinth morphology ( J:258919 )

• at E11.5, the placental labyrinth layer is malformed

placental labyrinth hypoplasia ( J:258919 )

• at E11.5, the placental labyrinth layer is hypoplastic

small placenta ( J:258919 )

• placenta area is significantly reduced at E10.5

abnormal placenta development ( J:258919 )

growth/size/body

embryonic growth retardation ( J:258919 )

• about one third of surviving embryos show growth retardation at E10.5

skeleton

abnormal sternocostal joint morphology ( J:258919 )

• fusion of ribs on 15 to the sternum in 32% of newborn mice

increased rib number ( J:258919 )

• an ectopic sternal rib (labeled as 15) is observed in newborn mice

rib fusion ( J:258919 )

• fusion of rib(s) on 9 to 8 in 7% of newborn mice

thoracic vertebral transformation ( J:258919 )

• prominent spinous process on 10, which is normally on 9, in 14% of newborn mice

abnormal arcus anterior morphology ( J:258919 )

• association of the anterior arch of the atlas with the atlas in 21% of newborn mice

cervical vertebral transformation ( J:258919 )

• anterior tubercle(s) on vertebra 7, which are normally on vertebra 6, in 18% of newborn mice

hematopoietic system

decreased nucleated erythrocyte cell number ( J:258919 )

• at E11.5, no fetus-derived nucleated erythrocytes are observed in the labyrinth layer, unlike in wild-type controls