Phenotypes associated with this allele

• Allele Symbol: Kcns1^tm1.1Kcl
• Allele Name: targeted mutation 1.1, King's College of London
• Allele ID: MGI:6357176
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kcns1^tm1.1Kcl/Kcns1^tm1.1Kcl Tg(Avil-icre/ERT2)AJwo/0	involves: 129S7/SvEvBrd * C57BL/6J	MGI:6357188

Genotype
MGI:6357188

cn1

• Allelic Composition: Kcns1^tm1.1Kcl/Kcns1^tm1.1Kcl; Tg(Avil-icre/ERT2)AJwo/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced coordination ( J:276188 )

• on a rotarod in tamoxifen-treated mice

abnormal mechanical nociception ( J:276188 )

• reduced threshold in tamoxifen-treated mice; more pronounced in female mice

• reduced threshold following neuropathic pain induced by nerve injury in tamoxifen-treated mice

• however, hot or cold thermal nociception is normal

hyperalgesia ( J:276188 )

• in response to mechanical pain following neuropathic pain induced by nerve injury in tamoxifen-treated mice

hyperresponsive to tactile stimuli ( J:276188 )

• reduced threshold in tamoxifen-treated mice; more pronounced in female mice

• however, hot or cold thermal nociception is normal

decreased thermal nociceptive threshold ( J:276188 )

• to innocuous and noxious cold temperatures pain following neuropathic pain induced by nerve injury in tamoxifen-treated mice

• however, hot thermal nociception in a neuropathic pain model is normal