All Phenotypes Mapkapk2<tm1.1Gkl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mapkapk2^tm1.1Gkl
targeted mutation 1.1, George Kollias
MGI:6357678

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mapkapk2^tm1.1Gkl/Mapkapk2^tm1.1Gkl Tg(Tie1-cre)9Ref/0	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	MGI:6357719
cn2	Apc^Min/Apc⁺ Mapkapk2^tm1.1Gkl/Mapkapk2^tm1.1Gkl Tg(Tie1-cre)9Ref/0	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	MGI:6357721
cn3	Mapkapk2^tm1.1Gkl/Mapkapk2^tm1.1Gkl Twist2^{tm1.1(cre)Dor}/Twist2⁺	involves: 129X1/SvJ * BALB/cJ * C57BL/6	MGI:6357718
cn4	Apc^Min/Apc⁺ Mapkapk2^tm1.1Gkl/Mapkapk2^tm1.1Gkl Twist2^{tm1.1(cre)Dor}/Twist2⁺	involves: 129X1/SvJ * BALB/cJ * C57BL/6J	MGI:6357723

Allelic Composition	Mapkapk2^tm1.1Gkl/Mapkapk2^tm1.1Gkl Tg(Tie1-cre)9Ref/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk2^tm1.1Gkl mutation (1 available); any Mapkapk2 mutation (35 available)
Tg(Tie1-cre)9Ref mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:262876 )

• smaller tumors induced by AOM/DSS

• however, development of induced colitis is normal

neoplasm

decreased incidence of tumors by chemical induction ( J:262876 )

• smaller tumors induced by AOM/DSS

• however, development of induced colitis is normal

Allelic Composition	Apc^Min/Apc⁺ Mapkapk2^tm1.1Gkl/Mapkapk2^tm1.1Gkl Tg(Tie1-cre)9Ref/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (158 available)
Mapkapk2^tm1.1Gkl mutation (1 available); any Mapkapk2 mutation (35 available)
Tg(Tie1-cre)9Ref mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:262876 )

• reduced proliferation and increased apoptosis of tumor cells compared to in Apc^min heterozygotes

Allelic Composition	Mapkapk2^tm1.1Gkl/Mapkapk2^tm1.1Gkl Twist2^{tm1.1(cre)Dor}/Twist2⁺
Genetic Background	involves: 129X1/SvJ * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk2^tm1.1Gkl mutation (1 available); any Mapkapk2 mutation (35 available)
Twist2^{tm1.1(cre)Dor} mutation (1 available); any Twist2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:262876 )

• fewer smaller tumors induced by AOM/DSS

• however, development of induced colitis is normal

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:262876 )

• fewer smaller tumors induced by AOM/DSS

• however, development of induced colitis is normal

Allelic Composition	Apc^Min/Apc⁺ Mapkapk2^tm1.1Gkl/Mapkapk2^tm1.1Gkl Twist2^{tm1.1(cre)Dor}/Twist2⁺
Genetic Background	involves: 129X1/SvJ * BALB/cJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:262876 )

• compared with Apc^min heterozygotes

• reduced proliferation and increased apoptosis of tumor cells compared with Apc^min heterozygotes

decreased tumor incidence ( J:262876 )

• compared with Apc^min heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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