Phenotypes associated with this allele

• Allele Symbol: Ncapd3^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6357830
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ncapd3^em1(IMPC)J/Ncapd3^em1(IMPC)J	C57BL/6NJ-Ncapd3^em1(IMPC)J/Mmjax	MGI:6492970
ht2	Ncapd3^em1(IMPC)J/Ncapd3^+	C57BL/6NJ-Ncapd3^em1(IMPC)J/Mmjax	MGI:7317024

Genotype
MGI:6492970

hm1

• Allelic Composition: Ncapd3^em1(IMPC)J/Ncapd3^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Ncapd3^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Ncapd3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ncapd3^em1(IMPC)J/Ncapd3^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form outgrowths.

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• blastocyst-like embryos are recovered at E3.5 (13% versus expected 25%, n=31); no homozygous embryos are recovered at E7.5 but excess resorption sites suggest that embryos elicit a decidual response in vivo

• in vitro, blastocysts hatch from the zona pellucida and form outgrowths after 3 days in culture

Genotype
MGI:7317024

ht2

• Allelic Composition: Ncapd3^em1(IMPC)J/Ncapd3⁺
• Genetic Background: C57BL/6NJ-Ncapd3^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Ncapd3

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

♂

IMPC - JAX

increased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - JAX

increased circulating phosphate level ( J:211773 )

IMPC - JAX

increased circulating aspartate transaminase level ( J:211773 )

♀

IMPC - JAX