Phenotypes associated with this allele

• Allele Symbol: Mecr^{tm1d(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:6357882
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mecr^tm1d(EUCOMM)Wtsi/Mecr^tm1d(EUCOMM)Wtsi	involves: C57BL/6 * C57BL/6JOlaHsd * C57BL/6N * SJL	MGI:6391000

Genotype
MGI:6391000

hm1

• Allelic Composition: Mecr^{tm1d(EUCOMM)Wtsi}/Mecr^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6JOlaHsd * C57BL/6N * SJL
• Cell Lines: EPD0039_5_G01

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:242847 )

• homozygous mutant embryos die between E9.5 and E11.5

• some embryos are already dead or dying at E9.5; all embryos are found dead and at varying stages of resorption at E11.5

embryo

embryonic growth retardation ( J:242847 )

• embryos found alive at E9.5 exhibit a developmental delay with retention of dorsal curvature, resembling wild-type E8.5 embryos, and adherent fetal membranes

decreased embryo size ( J:242847 )

• embryos are smaller in size by E8.5; those found alive at E9.5 are also smaller

abnormal placenta morphology ( J:242847 )

• at E9.5, the fetal placenta is much thinner and disorganized

abnormal trophoblast giant cell morphology ( J:242847 )

• at E9.5, organization of trophoblast giant cells is poor

abnormal spongiotrophoblast layer morphology ( J:242847 )

• at E9.5, organization of spongiotrophoblasts is poor

abnormal placenta fetal blood space morphology ( J:242847 )

• at E9.5, fetal blood spaces in labyrinth are not evident

abnormal placenta intervillous maternal lacunae morphology ( J:242847 )

• at E9.5, maternal blood spaces are not evident

disorganized placental labyrinth ( J:242847 )

• at E9.5, organization of the labyrinthine layer of the fetal part of placenta is poor

growth/size/body

embryonic growth retardation ( J:242847 )

• embryos found alive at E9.5 exhibit a developmental delay with retention of dorsal curvature, resembling wild-type E8.5 embryos, and adherent fetal membranes

decreased embryo size ( J:242847 )

• embryos are smaller in size by E8.5; those found alive at E9.5 are also smaller

integument

pallor ( J:242847 )

• embryos found alive at E10.5 are pale