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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mecrtm1.1(fabI)Akast
targeted mutation 1.1, Alexander J Kastaniotis
MGI:6357890
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mecrtm1.1(fabI)Akast/Mecrtm1.1(fabI)Akast involves: C57BL/6 * C57BL/6JOlaHsd * C57BL/6N * SJL MGI:6391012


Genotype
MGI:6391012
hm1
Allelic
Composition
Mecrtm1.1(fabI)Akast/Mecrtm1.1(fabI)Akast
Genetic
Background
involves: C57BL/6 * C57BL/6JOlaHsd * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecrtm1.1(fabI)Akast mutation (0 available); any Mecr mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous mutant embryos die between E10.5 and E11.5; all embryos are dead and at varying stages of resorption at E11.5
• no mouse embryonic fibroblasts could be established

embryo
• at E10.5, yolk sac vessels are pale and empty
• at E10.5, all embryos are smaller than heterozygous or wild-type embryos
• at E9.5, the fetal placenta is much thinner and disorganized
• at E9.5, organization of trophoblast giant cells is poor
• at E9.5, trophoblast giant cell layers are markedly thinner
• at E9.5, organization of spongiotrophoblasts is poor
• at E9.5, spongiotrophoblast layers are markedly thinner
• EM revealed failure of differentiation of labyrinthine trophoblasts as well as maternal and fetal blood spaces in labyrinth at E9.5
• at E9.5, fetal blood spaces in labyrinth are not evident
• at E9.5, maternal blood spaces are not evident
• at E9.5, the labyrinthine layer of the fetal part of placenta is poorly organized
• defects in placental development associated with disturbed peroxisome proliferator-activated receptor signaling

growth/size/body
• at E10.5, all embryos are smaller than heterozygous or wild-type embryos

cardiovascular system
• at E10.5, yolk sac vessels are pale and empty
• at E10.5, hearts are underdeveloped and resemble embryonic hearts at E8.5-E9.5
• the primitive atrial chamber and ventricle are the only discernible chambers at E10.5; however, trabeculation in myocardial wall of ventricular chambers is visible
• micro-computed tomography revealed that heart and cavity volumes are 19% and 21% smaller, respectively, than in controls and only a two chambered heart is present
• micro-computed tomography revealed that heart and cavity volumes are 19% and 21% smaller, respectively, than in controls and only a two chambered heart is present at E10.5
• at E10.5, heart beats are weak or absent
• at E10.5, heart beats are weak or absent

cellular
• at E9.5, mitochondria in labyrinthine trophoblasts appear clustered, irregular in shape and electron-lucent with no clear cristae structure
• analysis of several mitochondrial parameters revealed a reduced rate of mitochondrial respiration in permeabilized cells

integument
• at E10.5, all embryos are pale and fragile





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory