Phenotypes associated with this allele

• Allele Symbol: Set^tm1.1Wgu
• Allele Name: targeted mutation 1.1, Wei Gu
• Allele ID: MGI:6357923
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Set^tm1.1Wgu/Set^tm1.1Wgu	involves: 129S6/SvEvTac	MGI:6357934
cx2	Set^tm1.1Wgu/Set^tm1.1Wgu Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * 129S6/SvEvTac	MGI:6357935

Genotype
MGI:6357934

hm1

• Allelic Composition: Set^tm1.1Wgu/Set^tm1.1Wgu
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:276962 )

• all embryos die between E11.5 and E12.5

embryo

decreased embryo size ( J:276962 )

• at E9.5 and E10.5

• by E11.5 embryos are less than 20% the size of littermate controls

open neural tube ( J:276962 )

• at E10.5

homeostasis/metabolism

cardiac edema ( J:276962 )

• at E10.5

growth/size/body

decreased embryo size ( J:276962 )

• at E9.5 and E10.5

• by E11.5 embryos are less than 20% the size of littermate controls

nervous system

open neural tube ( J:276962 )

• at E10.5

Genotype
MGI:6357935

cx2

• Allelic Composition: Set^tm1.1Wgu/Set^tm1.1Wgu; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

mortality/aging

prenatal lethality, complete penetrance ( J:276962 )

• while no viable double homozygous mice are seen at birth, viable and morphologically normal double homozygous mice are found at E11.5 and E13.5 indicating a delay in lethality compared to mice homozygous for Set^tm1.1Wgu alone