All Phenotypes Knl1<tm1c(EUCOMM)Hmgu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Knl1^{tm1c(EUCOMM)Hmgu}/Knl1^{tm1c(EUCOMM)Hmgu} Trp53^tm1Brn/Trp53^tm1Brn Tg(GFAP-cre)25Mes/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N * FVB/N	MGI:6358254
cn2	Knl1^{tm1c(EUCOMM)Hmgu}/Knl1^{tm1c(EUCOMM)Hmgu} Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6N	MGI:6358251
cn3	Knl1^{tm1c(EUCOMM)Hmgu}/Knl1^{tm1c(EUCOMM)Hmgu} Tg(GFAP-cre)25Mes/0	involves: 129S4/SvJaeSor * C57BL/6N * FVB/N	MGI:6358252

Allelic Composition	Knl1^{tm1c(EUCOMM)Hmgu}/Knl1^{tm1c(EUCOMM)Hmgu} Trp53^tm1Brn/Trp53^tm1Brn Tg(GFAP-cre)25Mes/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N * FVB/N
Cell Lines	HEPD0665_2_E05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Knl1^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Knl1 mutation (104 available)
Tg(GFAP-cre)25Mes mutation (2 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:278483 )

nervous system

nervous system phenotype ( J:278483 )

N	• neuron loss is rescued by conditional knock-out of Trp53

telencephalon hypoplasia ( J:278483 )

• partially rescued by conditional knock-out of Trp53

cellular

aneuploidy ( J:278483 )

increased apoptosis ( J:278483 )

• partial rescue of apoptosis and DNA damage by conditional knock-out of Trp53

growth/size/body

microcephaly ( J:278483 )

• partially rescued by conditional knock-out of Trp53

Allelic Composition	Knl1^{tm1c(EUCOMM)Hmgu}/Knl1^{tm1c(EUCOMM)Hmgu} Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6N
Cell Lines	HEPD0665_2_E05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Knl1^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Knl1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

telencephalon hypoplasia ( J:278483 )

decreased neuron number ( J:278483 )

• in deep and upper layers

growth/size/body

microcephaly ( J:278483 )

• more severe than in mice with the conditional activated by Tg(GFAP-cre)25Mes

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:278483 )

postnatal lethality, incomplete penetrance ( J:278483 )

nervous system

premature neuronal precursor differentiation ( J:278483 )

• neural progenitor cells prematurely exhibit the cell cycle and become migratory

microgliosis ( J:278483 )

• mis-segregated chromosomes with DNA bridges located at the cleavage furrow

• however, karyotypes are normal

thin cortical plate ( J:278483 )

absent corpus callosum ( J:278483 )

telencephalon hypoplasia ( J:278483 )

decreased neuronal precursor cell number ( J:278483 )

• at E15.5 and E16.5 with some precursor cells located outside the ventricular zone and subventricular zone

decreased neuron number ( J:278483 )

• POU3F2-expressing L2-5 neurons

• CUX1-expressing L2-4 neurons

• due to increased apoptosis

• however, deep layer neuron numbers are normal

cellular

abnormal mitotic cytokinesis ( J:278483 )

• mis-segregated chromosomes with DNA bridges located at the cleavage furrow

• however, karyotypes are normal

increased apoptosis ( J:278483 )

• in the cortex at E15.5, abundant in the germinal zones and intermediate zone

• marginally by E17.5

• associated with increased DNA damage determined by gammaH2AX staining

• however, apoptotic cells are largely absent from the cortical plate

premature neuronal precursor differentiation ( J:278483 )

• neural progenitor cells prematurely exhibit the cell cycle and become migratory

abnormal double-strand DNA break repair ( J:278483 )

• increased DSB repair

growth/size/body

microcephaly ( J:278483 )

• less severe than in mice with the conditional activated by Emx1^tm1(cre)Krj

decreased body size ( J:278483 )

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:278483 )

• increased DSB repair

immune system

microgliosis ( J:278483 )

• mis-segregated chromosomes with DNA bridges located at the cleavage furrow

• however, karyotypes are normal

hematopoietic system

microgliosis ( J:278483 )

• mis-segregated chromosomes with DNA bridges located at the cleavage furrow

• however, karyotypes are normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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