Phenotypes associated with this allele

• Allele Symbol: Mettl14^tm1.1Czhao
• Allele Name: targeted mutation 1.1, Jing Crystal Zhao
• Allele ID: MGI:6358166
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mettl14^tm1.1Czhao/Mettl14^tm1.1Czhao Tg(Nes-cre)1Kln/0	involves: 129S6/SvEvTac * C57BL/6NCrl * SJL	MGI:6358181

Genotype
MGI:6358181

cn1

• Allelic Composition: Mettl14^tm1.1Czhao/Mettl14^tm1.1Czhao; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:258043 )

• all mice die within the first neonatal week

nervous system

decreased radial glial cell number ( J:258043 )

• in the cortex at E15.5 and E17.5 due to reduced proliferation

enlarged brain ventricles ( J:258043 )

• at P0

thin cerebral cortex ( J:258043 )

• moderate

• reduced thickness of the Cux1+ layers (II-IV) as early as E17.5

decreased neuron number ( J:258043 )

• reduced late-born neurons within the Cux1+ layers (II-IV) of the cortex as early as E17.5

abnormal glial cell physiology ( J:258043 )

• reduced radial glial cell proliferation at E15.5 and E17.5 due to a disruption in cell cycle progression

• premature radial glial cell differentiation

• however, apoptosis rates are normal

cellular

decreased radial glial cell number ( J:258043 )

• in the cortex at E15.5 and E17.5 due to reduced proliferation