Phenotypes associated with this allele

• Allele Symbol: Mettl14^tm1.2Czhao
• Allele Name: targeted mutation 1.2, Jing Crustal Zhao
• Allele ID: MGI:6358167
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mettl14^tm1.2Czhao/Mettl14^tm1.2Czhao	involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N * SJL	MGI:6358183

Genotype
MGI:6358183

hm1

• Allelic Composition: Mettl14^tm1.2Czhao/Mettl14^tm1.2Czhao
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:258043 )

• most mice are dead at E7.5, E8.5 and E9.5

prenatal lethality, complete penetrance ( J:258043 )

• no live mice are produced from breeding heterozygotes

nervous system

premature neuronal precursor differentiation ( J:258043 )

abnormal neuronal stem cell physiology ( J:258043 )

• reduced neurosphere size due to reduced proliferation of neuronal stem cells

• however, apoptosis rates are normal

cellular

premature neuronal precursor differentiation ( J:258043 )

abnormal DNA methylation ( J:258043 )

• near total loss of m6A in polyadenylation RNAs in neurospheres