Analysis Tools
mortality/aging
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• mice exhibit an increase in mortality following pilocarpine-induced seizures
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behavior/neurological
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• mice exhibit increased seizure susceptibility induced by kainic acid or pilocarpine, with mice showing more severe seizures and shorter latency to initial behavioral abnormalities as well as to developing status epilepticus
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• mice show occasional spontaneous seizures following routine handling during cage changes
• seizures start with hypertonia of the neck and tail, followed by clonic forelimbs, sometimes bilaterally, and loss of posture and brief immobility is seen during the postictal period
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homeostasis/metabolism
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• mice exhibit an increase in mortality following pilocarpine-induced seizures
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nervous system
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• mice exhibit increased seizure susceptibility induced by kainic acid or pilocarpine, with mice showing more severe seizures and shorter latency to initial behavioral abnormalities as well as to developing status epilepticus
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• mice show occasional spontaneous seizures following routine handling during cage changes
• seizures start with hypertonia of the neck and tail, followed by clonic forelimbs, sometimes bilaterally, and loss of posture and brief immobility is seen during the postictal period
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• mice exhibit exacerbated neuronal damage/loss in the CA1 and CA3 regions of the hippocampus after kainic acid-induced seizures resulting in the loss and abnormal distribution of dentate gyrate granule cells
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astrocytosis
(
J:275180
)
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• mice exhibit an increase in the hyperplasia of hippocampal reactive astrocytes after kainic acid-induced seizures
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• mice exhibit increased synaptic plasticity after intra-amygdala kainic acid-induced seizures
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