Phenotypes associated with this allele

• Allele Symbol: Snx8^tm1Hbsh
• Allele Name: targeted mutation 1, H-B Shu
• Allele ID: MGI:6358176
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Snx8^tm1Hbsh/Snx8^tm1Hbsh	Not Specified	MGI:6717249

Genotype
MGI:6717249

hm1

• Allelic Composition: Snx8^tm1Hbsh/Snx8^tm1Hbsh
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:254306 )

N • mice exhibit normal numbers and compositions of major immune cells in peripheral lymph nodes, spleen, and thymus

N • serum levels of TNF-alpha and IL-6 induced by i.p. injection of mice with peptidoglycan plus D-gal are normal

abnormal macrophage physiology ( J:254306 )

• bone marrow-derived macrophages (BMDMs) show impaired IFNgamma-triggered induction of a subset of downstream genes

decreased macrophage cytokine production ( J:254306 )

• after IFN-gamma treatment, BMDMs show markedly reduced levels of secreted CXCL9 and CXCL10 relative to similarly treated wild-type cells

abnormal circulating chemokine level ( J:254306 )

• after i.p. injection of L. monocytogenes (4 x 10 cfu per mouse) for 6h, mice exhibit significantly lower serum CXCL9 levels relative to similarly treated wild-type controls

decreased circulating CXCL10 level ( J:254306 )

• after i.p. injection of L. monocytogenes (4 x 10 cfu per mouse) for 6h, mice exhibit significantly lower serum CXCL10 levels relative to similarly treated wild-type controls

decreased circulating tumor necrosis factor level ( J:254306 )

• after i.p. injection of L. monocytogenes (4 x 10 cfu per mouse) for 6h, mice exhibit significantly lower serum TNF-alpha levels relative to similarly treated wild-type controls

abnormal dendritic cell physiology ( J:254306 )

• bone marrow-derived dendritic cells (BMDCs) show impaired IFNgamma-triggered induction of a subset of downstream genes

• after IFN-gamma treatment, BMDCs show markedly reduced levels of secreted CXCL9 and CXCL10 relative to similarly treated wild-type cells

abnormal chemokine secretion ( J:254306 )

• after IFN-gamma treatment, bone-marrow-derived macrophages (BMDMs) and dendritic cells (BMDCs) show markedly reduced levels of secreted CXCL9 relative to similarly treated wild-type cells

decreased CXCL10 secretion ( J:254306 )

• after IFN-gamma treatment, BMDMs and BMDCs show markedly reduced levels of secreted CXCL10 relative to similarly treated wild-type cells

increased susceptibility to bacterial infection ( J:254306 )

• after i.p. injection of L. monocytogenes (4 x 10 cfu per mouse), mice exhibit significantly lower serum CXCL9, CXCL10 and TNF-alpha levels and higher bacterial loads in their livers and spleens relative to similarly infected wild-type controls

• however, serum levels of CCL2 (aka MCP1) and IL-1beta induced by L. monocytogenes infection are normal

increased susceptibility to bacterial infection induced morbidity/mortality ( J:254306 )

• after i.p. injection of L. monocytogenes at a high dose (5 x 10 cfu per mouse), mice exhibit a significantly reduced survival rate relative to similarly infected wild-type controls

homeostasis/metabolism

abnormal circulating chemokine level ( J:254306 )

• after i.p. injection of L. monocytogenes (4 x 10 cfu per mouse) for 6h, mice exhibit significantly lower serum CXCL9 levels relative to similarly treated wild-type controls

decreased circulating CXCL10 level ( J:254306 )

• after i.p. injection of L. monocytogenes (4 x 10 cfu per mouse) for 6h, mice exhibit significantly lower serum CXCL10 levels relative to similarly treated wild-type controls

decreased circulating tumor necrosis factor level ( J:254306 )

• after i.p. injection of L. monocytogenes (4 x 10 cfu per mouse) for 6h, mice exhibit significantly lower serum TNF-alpha levels relative to similarly treated wild-type controls

hematopoietic system

abnormal macrophage physiology ( J:254306 )

• bone marrow-derived macrophages (BMDMs) show impaired IFNgamma-triggered induction of a subset of downstream genes

decreased macrophage cytokine production ( J:254306 )

• after IFN-gamma treatment, BMDMs show markedly reduced levels of secreted CXCL9 and CXCL10 relative to similarly treated wild-type cells

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:254306 )

• after i.p. injection of L. monocytogenes at a high dose (5 x 10 cfu per mouse), mice exhibit a significantly reduced survival rate relative to similarly infected wild-type controls