All Phenotypes Mir31<em1Nju> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir31^em1Nju/Mir31^em1Nju	involves: C57BL/6J	MGI:6358363
cx2	Mir31^em1Nju/Mir31^em1Nju Tg(MMTV-PyVT)634Mul/0	involves: C57BL/6J * FVB/N	MGI:6358371

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:271420 )

• mammary glands show a reduction in lipid droplets and alveolar tissues

abnormal mammary gland development ( J:271420 )

• mammary glands of 6 and 10 week old mice show precocious alveolar differentiation, resembling glands in early pregnancy

• mice exhibit a smaller population of CD24+CD29^high mammary stem cells

• size of the Lgr5+ stem cell subpopulation is reduced in mammary glands

abnormal mammary gland embryonic development ( J:271420 )

• the number of proliferating cells is decreased in alveoli at 14.5 dpc

abnormal mammary gland growth during pregnancy ( J:271420 )

• mammary glands at mid-pregnancy (E14.5) show enhanced alveogenesis, presented as overt luminal feature and an increased number of intracellular lipid droplets and higher beta-casein expression

• the alveoli fail to fully develop in homozygous mothers at both 18.5 dpc and lactation day 2

abnormal mammary duct terminal end bud morphology ( J:271420 )

• reduction in the number of proliferating cells is seen in the terminal end buds of 6 week old dox-treated mice

abnormal mammary gland alveolus morphology ( J:271420 )

• mammary glands of 6 and 10 week old mice show precocious alveolar differentiation, resembling glands in early pregnancy

• the alveoli fail to fully develop in homozygous mothers at both 18.5 dpc and lactation day 2

• the number of proliferating cells is decreased in alveoli at 14.5 dpc

abnormal mammary gland physiology ( J:271420 )

• reduction in the number of proliferating cells is seen in the terminal end buds of 6 week old dox-treated mice

hypolactation ( J:271420 )

• milk content is decreased in glands

• pups nursed by homozygous mothers have less milk in their stomachs at lactation day 2

• by weaning, survival rates of pups from homozygous females is lower than those of wild-type mothers

integument

abnormal mammary gland morphology ( J:271420 )

• mammary glands show a reduction in lipid droplets and alveolar tissues

abnormal mammary gland development ( J:271420 )

• mammary glands of 6 and 10 week old mice show precocious alveolar differentiation, resembling glands in early pregnancy

• mice exhibit a smaller population of CD24+CD29^high mammary stem cells

• size of the Lgr5+ stem cell subpopulation is reduced in mammary glands

abnormal mammary gland embryonic development ( J:271420 )

• the number of proliferating cells is decreased in alveoli at 14.5 dpc

abnormal mammary gland growth during pregnancy ( J:271420 )

• mammary glands at mid-pregnancy (E14.5) show enhanced alveogenesis, presented as overt luminal feature and an increased number of intracellular lipid droplets and higher beta-casein expression

• the alveoli fail to fully develop in homozygous mothers at both 18.5 dpc and lactation day 2

abnormal mammary duct terminal end bud morphology ( J:271420 )

• reduction in the number of proliferating cells is seen in the terminal end buds of 6 week old dox-treated mice

abnormal mammary gland alveolus morphology ( J:271420 )

• mammary glands of 6 and 10 week old mice show precocious alveolar differentiation, resembling glands in early pregnancy

• the alveoli fail to fully develop in homozygous mothers at both 18.5 dpc and lactation day 2

• the number of proliferating cells is decreased in alveoli at 14.5 dpc

abnormal mammary gland physiology ( J:271420 )

• reduction in the number of proliferating cells is seen in the terminal end buds of 6 week old dox-treated mice

hypolactation ( J:271420 )

• milk content is decreased in glands

• pups nursed by homozygous mothers have less milk in their stomachs at lactation day 2

• by weaning, survival rates of pups from homozygous females is lower than those of wild-type mothers

reproductive system

abnormal mammary gland growth during pregnancy ( J:271420 )

• mammary glands at mid-pregnancy (E14.5) show enhanced alveogenesis, presented as overt luminal feature and an increased number of intracellular lipid droplets and higher beta-casein expression

• the alveoli fail to fully develop in homozygous mothers at both 18.5 dpc and lactation day 2

Allelic Composition	Mir31^em1Nju/Mir31^em1Nju Tg(MMTV-PyVT)634Mul/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir31^em1Nju mutation (0 available); any Mir31 mutation (5 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:271420 )

• overall survival time is longer than in single Tg(MMTV-PyVT)634Mul transgenic mice with mice showing a higher metastasis-free survival rate

neoplasm

decreased mammary gland tumor incidence ( J:271420 )

• development of primary mammary lesions is suppressed at 12 and 16 weeks of age compared to single Tg(MMTV-PyVT)634Mul transgenic mice

• tumors do not show malignant features and appear more like benign adenomas

• the number of proliferating cells is much lower in tumors

• marker analysis indicates a basal-to-luminal cell fate change in mammary tumor cells

• reduction in the percentage of the CD24+CD90+ cancer stem cell population in mammary tumors compared to Tg(MMTV-PyVT)634Mul tumors

• limiting-dilution transplantation assays indicate that tumor cells show an approximate 13-fold decrease in tumor-initiating ability

decreased metastatic potential ( J:271420 )

• mice show a reduction in metastatic foci in lungs compared to single Tg(MMTV-PyVT)634Mul transgenic mice

• mice show a higher metastasis-free survival rate compared to single Tg(MMTV-PyVT)634Mul transgenic mice

decreased tumor growth/size ( J:271420 )

• at 20 weeks of age, mammary gland tumors are much smaller than in single Tg(MMTV-PyVT)634Mul transgenic mice

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:271420 )

• development of primary mammary lesions is suppressed at 12 and 16 weeks of age compared to single Tg(MMTV-PyVT)634Mul transgenic mice

• tumors do not show malignant features and appear more like benign adenomas

• the number of proliferating cells is much lower in tumors

• marker analysis indicates a basal-to-luminal cell fate change in mammary tumor cells

• reduction in the percentage of the CD24+CD90+ cancer stem cell population in mammary tumors compared to Tg(MMTV-PyVT)634Mul tumors

• limiting-dilution transplantation assays indicate that tumor cells show an approximate 13-fold decrease in tumor-initiating ability

integument

decreased mammary gland tumor incidence ( J:271420 )

• development of primary mammary lesions is suppressed at 12 and 16 weeks of age compared to single Tg(MMTV-PyVT)634Mul transgenic mice

• tumors do not show malignant features and appear more like benign adenomas

• the number of proliferating cells is much lower in tumors

• marker analysis indicates a basal-to-luminal cell fate change in mammary tumor cells

• reduction in the percentage of the CD24+CD90+ cancer stem cell population in mammary tumors compared to Tg(MMTV-PyVT)634Mul tumors

• limiting-dilution transplantation assays indicate that tumor cells show an approximate 13-fold decrease in tumor-initiating ability

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24