All Phenotypes Mir31<em1Nju> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir31^em1Nju/Mir31^em1Nju	involves: C57BL/6J	MGI:6358363
cx2	Mir31^em1Nju/Mir31^em1Nju Tg(MMTV-PyVT)634Mul/0	involves: C57BL/6J * FVB/N	MGI:6358371

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:271420 )

• mammary glands show a reduction in lipid droplets and alveolar tissues

abnormal mammary gland development ( J:271420 )

• mammary glands of 6 and 10 week old mice show precocious alveolar differentiation, resembling glands in early pregnancy

• mice exhibit a smaller population of CD24+CD29^high mammary stem cells

• size of the Lgr5+ stem cell subpopulation is reduced in mammary glands

abnormal mammary gland embryonic development ( J:271420 )

• the number of proliferating cells is decreased in alveoli at 14.5 dpc

abnormal mammary gland growth during pregnancy ( J:271420 )

• mammary glands at mid-pregnancy (E14.5) show enhanced alveogenesis, presented as overt luminal feature and an increased number of intracellular lipid droplets and higher beta-casein expression

• the alveoli fail to fully develop in homozygous mothers at both 18.5 dpc and lactation day 2

abnormal mammary duct terminal end bud morphology ( J:271420 )

• reduction in the number of proliferating cells is seen in the terminal end buds of 6 week old dox-treated mice

abnormal mammary gland alveolus morphology ( J:271420 )

• mammary glands of 6 and 10 week old mice show precocious alveolar differentiation, resembling glands in early pregnancy

• the alveoli fail to fully develop in homozygous mothers at both 18.5 dpc and lactation day 2

• the number of proliferating cells is decreased in alveoli at 14.5 dpc

abnormal mammary gland physiology ( J:271420 )

• reduction in the number of proliferating cells is seen in the terminal end buds of 6 week old dox-treated mice

hypolactation ( J:271420 )

• milk content is decreased in glands

• pups nursed by homozygous mothers have less milk in their stomachs at lactation day 2

• by weaning, survival rates of pups from homozygous females is lower than those of wild-type mothers

integument

abnormal mammary gland morphology ( J:271420 )

• mammary glands show a reduction in lipid droplets and alveolar tissues

abnormal mammary gland development ( J:271420 )

• mammary glands of 6 and 10 week old mice show precocious alveolar differentiation, resembling glands in early pregnancy

• mice exhibit a smaller population of CD24+CD29^high mammary stem cells

• size of the Lgr5+ stem cell subpopulation is reduced in mammary glands

abnormal mammary gland embryonic development ( J:271420 )

• the number of proliferating cells is decreased in alveoli at 14.5 dpc

abnormal mammary gland growth during pregnancy ( J:271420 )

• mammary glands at mid-pregnancy (E14.5) show enhanced alveogenesis, presented as overt luminal feature and an increased number of intracellular lipid droplets and higher beta-casein expression

• the alveoli fail to fully develop in homozygous mothers at both 18.5 dpc and lactation day 2

abnormal mammary duct terminal end bud morphology ( J:271420 )

• reduction in the number of proliferating cells is seen in the terminal end buds of 6 week old dox-treated mice

abnormal mammary gland alveolus morphology ( J:271420 )

• mammary glands of 6 and 10 week old mice show precocious alveolar differentiation, resembling glands in early pregnancy

• the alveoli fail to fully develop in homozygous mothers at both 18.5 dpc and lactation day 2

• the number of proliferating cells is decreased in alveoli at 14.5 dpc

abnormal mammary gland physiology ( J:271420 )

• reduction in the number of proliferating cells is seen in the terminal end buds of 6 week old dox-treated mice

hypolactation ( J:271420 )

• milk content is decreased in glands

• pups nursed by homozygous mothers have less milk in their stomachs at lactation day 2

• by weaning, survival rates of pups from homozygous females is lower than those of wild-type mothers

reproductive system

abnormal mammary gland growth during pregnancy ( J:271420 )

• mammary glands at mid-pregnancy (E14.5) show enhanced alveogenesis, presented as overt luminal feature and an increased number of intracellular lipid droplets and higher beta-casein expression

• the alveoli fail to fully develop in homozygous mothers at both 18.5 dpc and lactation day 2

Allelic Composition	Mir31^em1Nju/Mir31^em1Nju Tg(MMTV-PyVT)634Mul/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir31^em1Nju mutation (0 available); any Mir31 mutation (4 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:271420 )

• overall survival time is longer than in single Tg(MMTV-PyVT)634Mul transgenic mice with mice showing a higher metastasis-free survival rate

neoplasm

decreased mammary gland tumor incidence ( J:271420 )

• development of primary mammary lesions is suppressed at 12 and 16 weeks of age compared to single Tg(MMTV-PyVT)634Mul transgenic mice

• tumors do not show malignant features and appear more like benign adenomas

• the number of proliferating cells is much lower in tumors

• marker analysis indicates a basal-to-luminal cell fate change in mammary tumor cells

• reduction in the percentage of the CD24+CD90+ cancer stem cell population in mammary tumors compared to Tg(MMTV-PyVT)634Mul tumors

• limiting-dilution transplantation assays indicate that tumor cells show an approximate 13-fold decrease in tumor-initiating ability

decreased metastatic potential ( J:271420 )

• mice show a reduction in metastatic foci in lungs compared to single Tg(MMTV-PyVT)634Mul transgenic mice

• mice show a higher metastasis-free survival rate compared to single Tg(MMTV-PyVT)634Mul transgenic mice

decreased tumor growth/size ( J:271420 )

• at 20 weeks of age, mammary gland tumors are much smaller than in single Tg(MMTV-PyVT)634Mul transgenic mice

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:271420 )

• development of primary mammary lesions is suppressed at 12 and 16 weeks of age compared to single Tg(MMTV-PyVT)634Mul transgenic mice

• tumors do not show malignant features and appear more like benign adenomas

• the number of proliferating cells is much lower in tumors

• marker analysis indicates a basal-to-luminal cell fate change in mammary tumor cells

• reduction in the percentage of the CD24+CD90+ cancer stem cell population in mammary tumors compared to Tg(MMTV-PyVT)634Mul tumors

• limiting-dilution transplantation assays indicate that tumor cells show an approximate 13-fold decrease in tumor-initiating ability

integument

decreased mammary gland tumor incidence ( J:271420 )

• development of primary mammary lesions is suppressed at 12 and 16 weeks of age compared to single Tg(MMTV-PyVT)634Mul transgenic mice

• tumors do not show malignant features and appear more like benign adenomas

• the number of proliferating cells is much lower in tumors

• marker analysis indicates a basal-to-luminal cell fate change in mammary tumor cells

• reduction in the percentage of the CD24+CD90+ cancer stem cell population in mammary tumors compared to Tg(MMTV-PyVT)634Mul tumors

• limiting-dilution transplantation assays indicate that tumor cells show an approximate 13-fold decrease in tumor-initiating ability

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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