Phenotypes associated with this allele

• Allele Symbol: Ifi204^tm1.1Cjul
• Allele Name: targeted mutation 1.1, Chuan-ju Liu
• Allele ID: MGI:6358241
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifi204^tm1.1Cjul/Ifi204^tm1.1Cjul	B6.129(Cg)-Ifi204^tm1.1Cjul	MGI:6358243

Genotype
MGI:6358243

hm1

• Allelic Composition: Ifi204^tm1.1Cjul/Ifi204^tm1.1Cjul
• Genetic Background: B6.129(Cg)-Ifi204^tm1.1Cjul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating interferon-beta level ( J:270123 )

• mice intraperitoneally injected with LPS show lower serum levels of the pro-inflammatory cytokine IFN-beta

• levels of serum IFN-beta after LPS injection are decreased at 1 hour after injection but return to normal levels at 3 and 6 hours after injection

decreased circulating interleukin-1 beta level ( J:270123 )

• mice intraperitoneally injected with LPS show lower serum levels of the pro-inflammatory cytokine IL-1beta

• levels of serum IL-1beta after LPS injection are continuously lower from 1 hour up to 6 hours after LPS injection

decreased circulating interleukin-6 level ( J:270123 )

• mice intraperitoneally injected with LPS show lower serum levels of the pro-inflammatory cytokine IL-6

• levels of serum IL-6 after LPS injection are continuously lower from 1 hour up to 6 hours after LPS injection

decreased circulating tumor necrosis factor level ( J:270123 )

• mice intraperitoneally injected with LPS show lower serum levels of the pro-inflammatory cytokine TNF-alpha

• levels of serum TNF-alpha after LPS injection are continuously lower from 1 hour up to 6 hours after LPS injection

immune system

decreased circulating interferon-beta level ( J:270123 )

• mice intraperitoneally injected with LPS show lower serum levels of the pro-inflammatory cytokine IFN-beta

• levels of serum IFN-beta after LPS injection are decreased at 1 hour after injection but return to normal levels at 3 and 6 hours after injection

decreased circulating interleukin-1 beta level ( J:270123 )

• mice intraperitoneally injected with LPS show lower serum levels of the pro-inflammatory cytokine IL-1beta

• levels of serum IL-1beta after LPS injection are continuously lower from 1 hour up to 6 hours after LPS injection

decreased circulating interleukin-6 level ( J:270123 )

• mice intraperitoneally injected with LPS show lower serum levels of the pro-inflammatory cytokine IL-6

• levels of serum IL-6 after LPS injection are continuously lower from 1 hour up to 6 hours after LPS injection

decreased circulating tumor necrosis factor level ( J:270123 )

• mice intraperitoneally injected with LPS show lower serum levels of the pro-inflammatory cytokine TNF-alpha

• levels of serum TNF-alpha after LPS injection are continuously lower from 1 hour up to 6 hours after LPS injection

decreased interferon-beta secretion ( J:270123 )

• bone marrow derived macrophages show reduced IFN-beta production in response to intracellular viral DNAs and extracellular bacterial components

• bone marrow derived macrophages challenged with LPS show strongly suppressed production of the pro-inflammatory cytokine IFN-beta

• however, differentiation of macrophages and dendritic cells is not affected

decreased interleukin-6 secretion ( J:270123 )

• bone marrow derived macrophages challenged with LPS show strongly suppressed production of the pro-inflammatory cytokine IL-6

• bone marrow derived macrophages show lost responses to cytosolic DNA sensor cGAMP and the ligand of TLR2 PAM3Cys to produce IL-6

decreased tumor necrosis factor secretion ( J:270123 )

• bone marrow derived macrophages challenged with LPS show strongly suppressed production of the pro-inflammatory cytokine TNF-alpha

• bone marrow derived macrophages show lost responses to cytosolic DNA sensor cGAMP and the ligand of TLR2 PAM3Cys to produce TNF-alpha

decreased susceptibility to endotoxin shock ( J:270123 )

• mice injected with a lethal dose of LPS to induce acute septic shock show delayed onset of morbidity compared to wild-type mice, with 75% of mice surviving up to 100 hours under lethal dose of LPS compared to severe morbidity in 80% of wild-type mice within 40 hours

• however, bone marrow derived macrophages primed with Pam3CSK4 and transfected with LPS show induction of pyroptosis and IL-1 beta and IL-18 secretion similarly to wild-type mice