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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Commd3tm1.1Ksuz
targeted mutation 1.1, Kazuhiro Suzuki
MGI:6358284
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd79atm1(cre)Reth/Cd79a+
Commd3tm1.1Ksuz/Commd3tm1.1Ksuz 		involves: BALB/c * C57BL/6NSlc * SJL MGI:6358355


Genotype
MGI:6358355
cn1
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Commd3tm1.1Ksuz/Commd3tm1.1Ksuz
Genetic
Background		 involves: BALB/c * C57BL/6NSlc * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Commd3tm1.1Ksuz mutation (0 available); any Commd3 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:278399 )
N
• mice exhibit normal size of developing B cell subsets and serum levels of IgG3 and IgA in unimmunized mice
decreased mature B cell number ( J:278399 )
• in the bone marrow, blood, and spleen
decreased follicular B cell number ( J:278399 )
• in the bone marrow, blood, and spleen
abnormal plasmablast number ( J:278399 )
• decreased after immunization with NP-CGG compared with controls
abnormal spleen B cell follicle morphology ( J:278399 )
• less defined boundaries
decreased spleen germinal center number ( J:278399 )
• after immunization with NP-CGG compared with controls
abnormal follicular B cell physiology ( J:278399 )
• impaired B cell migration in response to CXCL12, CXCL13, CCL19 and 7alpha,25-HC
• bone marrow chimeras exhibit increased migration of B cells from follicles compared with wild-derived cells
• however, response to S1P is normal as is lymph node egression
decreased IgG1 level ( J:278399 )
• in unimmunized mice and after immunization with NP-CGG compared with controls
decreased IgG2b level ( J:278399 )
• in unimmunized mice
decreased IgG2c level ( J:278399 )
• in unimmunized mice
decreased IgM level ( J:278399 )
• in unimmunized mice and after immunization with NP-CGG compared with controls

hematopoietic system
decreased mature B cell number ( J:278399 )
• in the bone marrow, blood, and spleen
decreased follicular B cell number ( J:278399 )
• in the bone marrow, blood, and spleen
abnormal plasmablast number ( J:278399 )
• decreased after immunization with NP-CGG compared with controls
abnormal spleen B cell follicle morphology ( J:278399 )
• less defined boundaries
decreased spleen germinal center number ( J:278399 )
• after immunization with NP-CGG compared with controls
abnormal follicular B cell physiology ( J:278399 )
• impaired B cell migration in response to CXCL12, CXCL13, CCL19 and 7alpha,25-HC
• bone marrow chimeras exhibit increased migration of B cells from follicles compared with wild-derived cells
• however, response to S1P is normal as is lymph node egression
decreased IgG1 level ( J:278399 )
• in unimmunized mice and after immunization with NP-CGG compared with controls
decreased IgG2b level ( J:278399 )
• in unimmunized mice
decreased IgG2c level ( J:278399 )
• in unimmunized mice
decreased IgM level ( J:278399 )
• in unimmunized mice and after immunization with NP-CGG compared with controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory