Phenotypes associated with this allele

• Allele Symbol: Chia1^tm1.1Lof
• Allele Name: targeted mutation 1.1, Lori J Fitz
• Allele ID: MGI:6358337
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chia1^tm1.1Lof/Chia1^tm1.1Lof	C57BL/6-Chia1^tm1.1Lof	MGI:6358360

Genotype
MGI:6358360

hm1

• Allelic Composition: Chia1^tm1.1Lof/Chia1^tm1.1Lof
• Genetic Background: C57BL/6-Chia1^tm1.1Lof

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased neutrophil cell number ( J:257728 )

• increased bronchoalveolar lavage (BAL) cell count after challenge with escalating doses of MCh, 24 hours after exposure to HDM

increased lymphocyte cell number ( J:257728 )

• increased bronchoalveolar lavage (BAL) cell count after challenge with escalating doses of MCh, 24 hours after exposure to HDM

immune system

immune system phenotype ( J:257728 )

N • normal immune response in OVA-induced pulmonary inflammation

N • normal allergen-induced airway hyperresponsiveness (AHR)

N • normal immune response to HDM exposure of airways

increased neutrophil cell number ( J:257728 )

• increased bronchoalveolar lavage (BAL) cell count after challenge with escalating doses of MCh, 24 hours after exposure to HDM

increased lymphocyte cell number ( J:257728 )

• increased bronchoalveolar lavage (BAL) cell count after challenge with escalating doses of MCh, 24 hours after exposure to HDM

decreased interleukin-13 secretion ( J:257728 )

• decreased bronchoalveolar lavage (BAL) Il-13 levels

respiratory system

respiratory system phenotype ( J:257728 )

N • normal immune response to HDM exposure of airways

N • normal allergen-induced airway hyperresponsiveness (AHR)

N • normal immune response in OVA-induced pulmonary inflammation