About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Morrbidem1Flv
endonuclease-mediated mutation 1, Richard A Flavell
MGI:6358426
Summary 4 genotypes


Genotype
MGI:6358496
hm1
Allelic
Composition		 Morrbidem1Flv/Morrbidem1Flv
Genetic
Background		 C57BL/6N-Morrbidem1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morrbidem1Flv mutation (0 available); any Morrbid mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
immune system phenotype ( J:236609 )
N
• mice exhibit normal eosinophil, neutrophil and monocyte progenitors
abnormal myelopoiesis ( J:236609 )
• reduced short-lived myeloid cells in mixed bone marrow chimeras
decreased eosinophil cell number ( J:236609 )
• in the blood and tissue
decreased neutrophil cell number ( J:236609 )
• in the blood and tissue
decreased Ly6C high monocyte number ( J:236609 )
• in the blood and tissue
abnormal leukocyte physiology ( J:236609 )
• increased apoptosis of monocytes in bone marrow cultured ex vivo
abnormal eosinophil physiology ( J:236609 )
• increased apoptosis in bone marrow cultured ex vivo and in vitro bone marrow-derived eosinophils
abnormal neutrophil physiology ( J:236609 )
• increased apoptosis in bone marrow cultured ex vivo
increased susceptibility to bacterial infection ( J:236609 )
• mice infected with Listeria monocytogenes exhibit increased mortality, body weight loss and colony forming units in the spleen and liver compared with wild-type mice

hematopoietic system
abnormal myelopoiesis ( J:236609 )
• reduced short-lived myeloid cells in mixed bone marrow chimeras
decreased eosinophil cell number ( J:236609 )
• in the blood and tissue
decreased neutrophil cell number ( J:236609 )
• in the blood and tissue
decreased Ly6C high monocyte number ( J:236609 )
• in the blood and tissue
abnormal leukocyte physiology ( J:236609 )
• increased apoptosis of monocytes in bone marrow cultured ex vivo
abnormal eosinophil physiology ( J:236609 )
• increased apoptosis in bone marrow cultured ex vivo and in vitro bone marrow-derived eosinophils
abnormal neutrophil physiology ( J:236609 )
• increased apoptosis in bone marrow cultured ex vivo




Genotype
MGI:6358497
ht2
Allelic
Composition		 Morrbidem1Flv/Morrbid+
Genetic
Background		 C57BL/6N-Morrbidem1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morrbidem1Flv mutation (0 available); any Morrbid mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased Ly6C high monocyte number ( J:236609 )
• in the blood, not as severe as in homozygotes

hematopoietic system
decreased Ly6C high monocyte number ( J:236609 )
• in the blood, not as severe as in homozygotes




Genotype
MGI:6358499
cx3
Allelic
Composition		 Bcl2l11em1Flv/Bcl2l11+
Morrbid+/Morrbidem1Flv
Genetic
Background		 C57BL/6N-Bcl2l11em1Flv +/+ Morrbidem1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11em1Flv mutation (0 available); any Bcl2l11 mutation (36 available)
Morrbidem1Flv mutation (0 available); any Morrbid mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased eosinophil cell number ( J:236609 )
• in the blood and spleen
decreased neutrophil cell number ( J:236609 )
• in the blood and spleen
decreased Ly6C high monocyte number ( J:236609 )
• in the blood and spleen

hematopoietic system
decreased eosinophil cell number ( J:236609 )
• in the blood and spleen
decreased neutrophil cell number ( J:236609 )
• in the blood and spleen
decreased Ly6C high monocyte number ( J:236609 )
• in the blood and spleen




Genotype
MGI:6358501
cx4
Allelic
Composition		 Bcl2l11em1Flv/Bcl2l11+
Morrbidem1Flv/Morrbid+
Genetic
Background		 C57BL/6N-Bcl2l11em1Flv Morrbidem1Flv /+ +
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11em1Flv mutation (0 available); any Bcl2l11 mutation (36 available)
Morrbidem1Flv mutation (0 available); any Morrbid mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:236609 )
N
• short-lived myeloid cell (eosinophils, neutrophils and monocytes) numbers are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory