All Phenotypes Zcwpw1<em1Kliu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zcwpw1^em1Kliu
endonuclease-mediated mutation 1, Kui Lui
MGI:6358521

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zcwpw1^em1Kliu/Zcwpw1^em1Kliu	C57BL/6-Zcwpw1^em1Kliu	MGI:6358553

Allelic Composition	Zcwpw1^em1Kliu/Zcwpw1^em1Kliu
Genetic Background	C57BL/6-Zcwpw1^em1Kliu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zcwpw1^em1Kliu mutation (0 available); any Zcwpw1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

absent oocytes ( J:278517 )

• by 8 months

abnormal chromosomal synapsis ( J:278517 )

• a large number of autosomes remain unsynapsed in spermatocytes and display impaired meiotic recombination

abnormal female meiosis ( J:278517 )

• delayed meiosis prophase I

• however, prophase I is successful

decreased mature ovarian follicle number ( J:278517 )

• at 6 months

abnormal ovarian folliculogenesis ( J:278517 )

• reduced follicle pool and premature ovarian insufficiency

absent mature ovarian follicles ( J:278517 )

• at around 8 months of age

• however, ovary morphology is normal up to mid-adulthood

small testis ( J:278517 )

abnormal spermatogenesis ( J:278517 )

azoospermia ( J:278517 )

• lack postmeiotic spermatocytes in the seminiferous tubules

• no spermatozoa in the epididymis

arrest of male meiosis ( J:278517 )

• spermatocytes fail to process beyond pachytene

female infertility ( J:278517 )

• after mid-adulthood

male infertility ( J:278517 )

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:278517 )

• in spermatocytes

cellular

absent oocytes ( J:278517 )

• by 8 months

azoospermia ( J:278517 )

• lack postmeiotic spermatocytes in the seminiferous tubules

• no spermatozoa in the epididymis

abnormal chromosomal synapsis ( J:278517 )

• a large number of autosomes remain unsynapsed in spermatocytes and display impaired meiotic recombination

abnormal female meiosis ( J:278517 )

• delayed meiosis prophase I

• however, prophase I is successful

arrest of male meiosis ( J:278517 )

• spermatocytes fail to process beyond pachytene

abnormal double-strand DNA break repair ( J:278517 )

• in spermatocytes

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:278517 )

• at 6 months

abnormal ovarian folliculogenesis ( J:278517 )

• reduced follicle pool and premature ovarian insufficiency

absent mature ovarian follicles ( J:278517 )

• at around 8 months of age

• however, ovary morphology is normal up to mid-adulthood

small testis ( J:278517 )

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