Phenotypes associated with this allele

• Allele Symbol: Shtn1^tm1Nngk
• Allele Name: targeted mutation 1, Naoyuki Inagaki
• Allele ID: MGI:6358574
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shtn1^tm1Nngk/Shtn1^tm1Nngk	B6.129-Shtn1^tm1Nngk	MGI:6358581

Genotype
MGI:6358581

hm1

• Allelic Composition: Shtn1^tm1Nngk/Shtn1^tm1Nngk
• Genetic Background: B6.129-Shtn1^tm1Nngk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:272349 )

• some mice die between P0 and P20

nervous system

abnormal axon fasciculation ( J:272349 )

• defasciculation of the anterior limbs of the anterior commissure

decreased hippocampal commissure size ( J:272349 )

• reduced thickness

abnormal anterior commissure morphology ( J:272349 )

• decreased thickness of the axon bundle that cross the midline and disruption of the anterior and posterior limbs of the commissure

• defasciculation of the anterior limbs of the anterior commissure and misprojection of the axons

decreased anterior commissure size ( J:272349 )

• reduced thickness

abnormal forebrain morphology ( J:272349 )

• absent septum in the forebrain

abnormal corpus callosum morphology ( J:272349 )

• decreased thickness of the axonal tracts at the midline and incomplete contralateral projections of callosal axons

decreased corpus callosum size ( J:272349 )

• reduced thickness

abnormal neocortex morphology ( J:272349 )

• lacks axonal tracks in the intermediate zone with ectopic axonal projections toward the cortical plate

cellular

abnormal axon fasciculation ( J:272349 )

• defasciculation of the anterior limbs of the anterior commissure