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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Orai2tm1.1Itl
targeted mutation 1.1, inGenious Targeting Laboratory
MGI:6358679
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Orai2tm1.1Itl/Orai2tm1.1Itl
Tg(Cma1-cre)#Roer/0 		involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N MGI:6358682


Genotype
MGI:6358682
cn1
Allelic
Composition		 Orai2tm1.1Itl/Orai2tm1.1Itl
Tg(Cma1-cre)#Roer/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Orai2tm1.1Itl mutation (0 available); any Orai2 mutation (14 available)
Tg(Cma1-cre)#Roer mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to type I hypersensitivity reaction ( J:278536 )
• mice sensitized with anti-DNP IgE and then treated with a solution containing DNP-HSA to induce passive systemic anaphylactic reaction show exacerbated anaphylaxis compared to controls, with mice showing delayed body temperature recovery




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory