Phenotypes associated with this allele

• Allele Symbol: Nin^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6358683
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nin^tm1c(EUCOMM)Hmgu/Nin^tm1c(EUCOMM)Hmgu Tg(KRT14-cre)1Ipc/0	involves: C57BL/6 * C57BL/6N * SJL	MGI:6358685

Genotype
MGI:6358685

cn1

• Allelic Composition: Nin^{tm1c(EUCOMM)Hmgu}/Nin^{tm1c(EUCOMM)Hmgu}; Tg(KRT14-cre)1Ipc/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired skin barrier function ( J:277726 )

• transepidermal water loss is increased in newborns, indicating that inside-out barrier is slightly compromised

integument

impaired skin barrier function ( J:277726 )

• transepidermal water loss is increased in newborns, indicating that inside-out barrier is slightly compromised

abnormal skin morphology ( J:277726 )

• skin shows reduced desmosome numbers and size

• desmosomes have an irregular morphology, with a faint, kinked desmoglea and with plaques appearing less dense with less keratin filaments attached

thin epidermis stratum basale ( J:277726 )

• relative thickness of the basal and spinous layers is 74% of wild-type

decreased keratohyalin granule number ( J:277726 )

decreased keratohyalin granule size ( J:277726 )

thin epidermis stratum granulosum ( J:277726 )

• the granular layer appears thinner, with cells that have less and smaller keratohyalin granules

• relative thickness of the granular layer is 49% of wild-type

thin epidermis stratum spinosum ( J:277726 )

• relative thickness of the basal and spinous layers is 74% of wild-type

thin epidermis ( J:277726 )

• newborns exhibit a thinner epidermis, with relative thickness of the epidermis being 67% of wild-type epidermis

thin skin ( J:277726 )

delayed skin barrier formation ( J:277726 )

• E17.5 mutants show dye penetration almost all over their surface indicating defective epidermal barrier formation, however by E18.5, epidermal barrier is normal and no dye penetration is seen