Phenotypes associated with this allele

• Allele Symbol: Cpne5^tm1Mfan
• Allele Name: targeted mutation 1, Ming Fan
• Allele ID: MGI:6358726
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpne5^tm1Mfan/Cpne5^tm1Mfan	B6.129-Cpne5^tm1Mfan	MGI:7424986

Genotype
MGI:7424986

hm1

• Allelic Composition: Cpne5^tm1Mfan/Cpne5^tm1Mfan
• Genetic Background: B6.129-Cpne5^tm1Mfan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:274122 )

N • adult homozygotes show normal total travel distance in the open field task, no memory deficits in the Y-maze and novelty recognition test, and normal time spent in the dark box of the light-dark box task relative to wild-type controls

decreased anxiety-related response ( J:274122 )

• in the elevated plus maze task, homozygotes spend significantly more time in the open arms and less time in the closed arms than controls, indicating a decreased anxiety level

• in the elevated platform task, homozygotes spend significantly more time in the outer zone and less time in the center and middle zone of the elevated platform

growth/size/body

growth/size/body region phenotype ( J:274122 )

N • adult homozygotes have normal body structure with no significant alterations in body weight relative to wild-type controls

nervous system

nervous system phenotype ( J:274122 )

N • adult homozygotes have normal whole brain structure and show no obvious abnormalities in cerebral cortex and hippocampus morphology relative to wild-type controls