Phenotypes associated with this allele

• Allele Symbol: Slc52a3^tm1.1Said
• Allele Name: targeted mutation 1.1, Hamid M Said
• Allele ID: MGI:6358739
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Slc52a3^tm1.1Said/Slc52a3^tm1.1Said Tg(Vil1-cre)997Gum/0	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N * SJL	MGI:6358742

Genotype
MGI:6358742

cn1

• Allelic Composition: Slc52a3^tm1.1Said/Slc52a3^tm1.1Said; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:278571 )

• two-thirds of mice die between 6 and 12 weeks

• however, drinking water supplementation with riboflavin reverses phenotype

skeleton

short femur ( J:278571 )

short tibia ( J:278571 )

abnormal pelvic girdle bone morphology ( J:278571 )

• short pelvic bone

decreased bone mineral density ( J:278571 )

• in femur and tibia

• however, drinking water supplementation with riboflavin reverses phenotype

decreased bone mineral density of femur ( J:278571 )

growth/size/body

decreased body weight ( J:278571 )

• however, drinking water supplementation with riboflavin reverses phenotype

postnatal growth retardation ( J:278571 )

behavior/neurological

lethargy ( J:278571 )

hunched posture ( J:278571 )

homeostasis/metabolism

abnormal vitamin level ( J:278571 )

• reduced serum riboflavin (vitamin B2) levels and reduced uptake levels in the jejunal loops, isolated enterocytes and colon

• however, biotin uptake levels are normal

vision/eye

abnormal ocular surface morphology ( J:278571 )

• however, drinking water supplementation with riboflavin reverses phenotype

limbs/digits/tail

short femur ( J:278571 )

short tibia ( J:278571 )