All Phenotypes Zc3h12c<tm2c(EUCOMM)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zc3h12c^{tm2c(EUCOMM)Hmgu}
targeted mutation 2c, Helmholtz Zentrum Muenchen GmbH
MGI:6359731

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Zc3h12c^{tm2c(EUCOMM)Hmgu}/Zc3h12c^{tm2c(EUCOMM)Hmgu} Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N	MGI:6359746
cn2	Zc3h12c^{tm2c(EUCOMM)Hmgu}/Zc3h12c^{tm2c(EUCOMM)Hmgu} Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N	MGI:6359749
cn3	Zc3h12c^{tm2c(EUCOMM)Hmgu}/Zc3h12c^{tm2c(EUCOMM)Hmgu} Tg(Cd4-cre)1Cwi/0	involves: 129S4/SvJaeSor * C57BL/6N * DBA/2	MGI:6359748

Allelic Composition	Zc3h12c^{tm2c(EUCOMM)Hmgu}/Zc3h12c^{tm2c(EUCOMM)Hmgu} Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Zc3h12c^{tm2c(EUCOMM)Hmgu} mutation (0 available); any Zc3h12c mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:277714 )

• in the lymph node

increased immature B cell number ( J:277714 )

• in the spleen

increased marginal zone B cell number ( J:277714 )

• in the spleen

increased CD4-positive, alpha-beta T cell number ( J:277714 )

• in the lymph node

increased effector memory CD8-positive, alpha-beta T cell number ( J:277714 )

• in the spleen

enlarged lymph nodes ( J:277714 )

• as in knock-out mice

hematopoietic system

increased B cell number ( J:277714 )

• in the lymph node

increased immature B cell number ( J:277714 )

• in the spleen

increased marginal zone B cell number ( J:277714 )

• in the spleen

increased CD4-positive, alpha-beta T cell number ( J:277714 )

• in the lymph node

increased effector memory CD8-positive, alpha-beta T cell number ( J:277714 )

• in the spleen

Allelic Composition	Zc3h12c^{tm2c(EUCOMM)Hmgu}/Zc3h12c^{tm2c(EUCOMM)Hmgu} Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Zc3h12c^{tm2c(EUCOMM)Hmgu} mutation (0 available); any Zc3h12c mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:277714 )

N	• mice exhibit normal B cell numbers and lymph node size

Allelic Composition	Zc3h12c^{tm2c(EUCOMM)Hmgu}/Zc3h12c^{tm2c(EUCOMM)Hmgu} Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6N * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation (10 available)
Zc3h12c^{tm2c(EUCOMM)Hmgu} mutation (0 available); any Zc3h12c mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:277714 )

N	• mice exhibit normal T cell viability and numbers and lymph node size

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