Phenotypes associated with this allele

• Allele Symbol: Zc3h12c^{tm2d(EUCOMM)Hmgu}
• Allele Name: targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6359732
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zc3h12c^tm2d(EUCOMM)Hmgu/Zc3h12c^tm2d(EUCOMM)Hmgu	involves: 129S4/SvJaeSor * C57BL/6N	MGI:6359750

Genotype
MGI:6359750

hm1

• Allelic Composition: Zc3h12c^{tm2d(EUCOMM)Hmgu}/Zc3h12c^{tm2d(EUCOMM)Hmgu}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:277714 )

N • mice do not develop systemic autoimmunity

decreased germinal center B cell number ( J:277714 )

• in the spleen

increased B cell number ( J:277714 )

• increased frequency in enlarged lymph nodes

increased immature B cell number ( J:277714 )

• slightly

increased marginal zone B cell number ( J:277714 )

• slightly

decreased CD8-positive, alpha-beta T cell number ( J:277714 )

increased T cell number ( J:277714 )

• increased number in enlarged lymph nodes

increased CD4-positive, alpha-beta T cell number ( J:277714 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:277714 )

decreased macrophage cell number ( J:277714 )

• with altered distribution

increased splenocyte number ( J:277714 )

• however, spleen size is normal

increased IgA level ( J:277714 )

• mild

increased IgG level ( J:277714 )

• mild

increased IgM level ( J:277714 )

• mild

increased circulating interferon-gamma level ( J:277714 )

abnormal lymph node cortex morphology ( J:277714 )

• disrupted B and T cell zones

abnormal lymph node primary follicle morphology ( J:277714 )

• destroyed follicle development

enlarged lymph nodes ( J:277714 )

• partial or complete enlargement of skin-draining lymph nodes (inguinal, superficial cervical, axillary, and brachial)

homeostasis/metabolism

increased circulating interferon-gamma level ( J:277714 )

hematopoietic system

extramedullary hematopoiesis ( J:277714 )

decreased germinal center B cell number ( J:277714 )

• in the spleen

increased B cell number ( J:277714 )

• increased frequency in enlarged lymph nodes

increased immature B cell number ( J:277714 )

• slightly

increased marginal zone B cell number ( J:277714 )

• slightly

decreased CD8-positive, alpha-beta T cell number ( J:277714 )

increased T cell number ( J:277714 )

• increased number in enlarged lymph nodes

increased CD4-positive, alpha-beta T cell number ( J:277714 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:277714 )

decreased macrophage cell number ( J:277714 )

• with altered distribution

increased myeloid cell number ( J:277714 )

• in enlarged lymph nodes

increased splenocyte number ( J:277714 )

• however, spleen size is normal

increased IgA level ( J:277714 )

• mild

increased IgG level ( J:277714 )

• mild

increased IgM level ( J:277714 )

• mild