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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gk2em#Juhu
endonuclease-mediated mutation, Junjiu Huang
MGI:6359789
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gk2em#Juhu/Gk2em#Juhu C57BL/6J-Gk2em#Juhu MGI:6359850
ht2
Gk2em#Juhu/Gk2+ C57BL/6J-Gk2em#Juhu MGI:6359852


Genotype
MGI:6359850
hm1
Allelic
Composition
Gk2em#Juhu/Gk2em#Juhu
Genetic
Background
C57BL/6J-Gk2em#Juhu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gk2em#Juhu mutation (0 available); any Gk2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• broken into multiple sections
• broken into multiple sections
• kinked at midpiece-principal piece junction in around 97% of sperm
• fewer spermatozoa in epididymis
• reduced motility, amplitude of lateral head movement, beat-cross frequency, and average path, curvilinear and straight-line velocity

reproductive system
N
• normal overall testis morphology
• broken into multiple sections
• broken into multiple sections
• kinked at midpiece-principal piece junction in around 97% of sperm
• fewer spermatozoa in epididymis
• reduced motility, amplitude of lateral head movement, beat-cross frequency, and average path, curvilinear and straight-line velocity
• when mated to wild-type females




Genotype
MGI:6359852
ht2
Allelic
Composition
Gk2em#Juhu/Gk2+
Genetic
Background
C57BL/6J-Gk2em#Juhu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gk2em#Juhu mutation (0 available); any Gk2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• kinked at midpiece-principal piece junction in around 14% of sperm
• reduced straight-line velocity

reproductive system
N
• normal overall testis morphology
• fertile
• kinked at midpiece-principal piece junction in around 14% of sperm
• reduced straight-line velocity





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory