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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gykl1em#Juhu
endonuclease-mediated mutation, Junjiu Huang
MGI:6359801
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gykl1em#Juhu/Gykl1em#Juhu C57BL/6J-Gykl1em#Juhu MGI:6359847
ht2
Gykl1em#Juhu/Gykl1+ C57BL/6J-Gykl1em#Juhu MGI:6359848


Genotype
MGI:6359847
hm1
Allelic
Composition
Gykl1em#Juhu/Gykl1em#Juhu
Genetic
Background
C57BL/6J-Gykl1em#Juhu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gykl1em#Juhu mutation (0 available); any Gykl1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• gap at midpiece-principal piece junction
• mitochondria concentration at end of sheath
• kinked at midpiece-principal piece junction in around 96% of sperm
• fewer spermatozoa in epididymis
• spermatozoa swim with heads facing backwards and with twisting tails
• reduced motility, amplitude of lateral head movement, beat-cross frequency, and average path, curvilinear and straight-line velocity

reproductive system
N
• normal overall testis morphology
• gap at midpiece-principal piece junction
• mitochondria concentration at end of sheath
• kinked at midpiece-principal piece junction in around 96% of sperm
• fewer spermatozoa in epididymis
• spermatozoa swim with heads facing backwards and with twisting tails
• reduced motility, amplitude of lateral head movement, beat-cross frequency, and average path, curvilinear and straight-line velocity
• when mated to wild-type females




Genotype
MGI:6359848
ht2
Allelic
Composition
Gykl1em#Juhu/Gykl1+
Genetic
Background
C57BL/6J-Gykl1em#Juhu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gykl1em#Juhu mutation (0 available); any Gykl1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• kinked at midpiece-principal piece junction in around 93% of sperm
• reduced amplitude of lateral head movement, beat-cross frequency, and average path, curvilinear and straight-line velocity

reproductive system
• kinked at midpiece-principal piece junction in around 93% of sperm
• reduced amplitude of lateral head movement, beat-cross frequency, and average path, curvilinear and straight-line velocity
• 50% reduction in litter size when mated to wild-type females





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory