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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc53tm1.1Gning
targeted mutation 1.1, Guang Ning
MGI:6359860
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mirc53tm1.1Gning/Mirc53tm1.1Gning
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6 * DBA MGI:6359866


Genotype
MGI:6359866
cn1
Allelic
Composition		 Mirc53tm1.1Gning/Mirc53tm1.1Gning
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc53tm1.1Gning mutation (0 available); any Mirc53 mutation (1 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased susceptibility to injury ( J:278082 )
• mice treated with methionine and choline deficient diet (MCDD) or chronic carbon tetrachloride (CCl4) exhibit reduced hepatic steatosis, fibrosis, and inflammatory infiltration with less severe increase in serum alanine transferase levels compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory