All Phenotypes Mir146<tm1.1Lfl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mir146^tm1.1Lfl
targeted mutation 1.1, Li-Fan Lu
MGI:6359885

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:6360061
cn2	Cd40^tm1Kik/Cd40⁺ Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:6360064
cn3	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(Cr2-cre)3Cgn/0	involves: C57BL/6	MGI:6360060
cn4	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(CD2-icre)4Kio/0	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:6360065
cn5	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:6360066
cn6	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Mir146b^tm1.1Lfl/Mir146b^tm1.1Lfl Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:6360068

Allelic Composition	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Mir146^tm1.1Lfl mutation (1 available); any Mir146 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased germinal center B cell number ( J:266124 )

• mild day 28 post immunization with sheep red blood cells

increased T follicular helper cell number ( J:266124 )

• mild day 28 post immunization with sheep red blood cells

hematopoietic system

increased germinal center B cell number ( J:266124 )

• mild day 28 post immunization with sheep red blood cells

increased T follicular helper cell number ( J:266124 )

• mild day 28 post immunization with sheep red blood cells

Allelic Composition	Cd40^tm1Kik/Cd40⁺ Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40^tm1Kik mutation (11 available); any Cd40 mutation (53 available)
Mir146^tm1.1Lfl mutation (1 available); any Mir146 mutation (9 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:266124 )

N	• mice exhibit a restoration of normal IgG1 levels in B cells compared with Mir146^tm1.1Tmmc Tg(Cr2-cre)3Cgn mice

increased T follicular helper cell number ( J:266124 )

• following immunization with sheep red blood cells in mixed bone marrow chimeras

hematopoietic system

increased T follicular helper cell number ( J:266124 )

• following immunization with sheep red blood cells in mixed bone marrow chimeras

Allelic Composition	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir146^tm1.1Lfl mutation (1 available); any Mir146 mutation (9 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased germinal center B cell number ( J:266124 )

• minimal in young un-immunized mice on GL7+PNA+, which is further exacerbated with age

• at 6 months of age in un-immunized mice

• in young mice immunized with sheep red blood cells

increased plasma cell number ( J:266124 )

• in young mice immunized with sheep red blood cells

increased T follicular helper cell number ( J:266124 )

• at 6 months of age in un-immunized mice

• in young mice immunized with sheep red blood cells

increased IgG level ( J:266124 )

• SRBC-specific in young mice immunized with sheep red blood cells (SRBC)

increased IgG1 level ( J:266124 )

• following immunization with 4-hydroxy-3-nitrophenyl linked to Keyhole Limpet Hemocyanin (KLH) (NP-KLH) in alum

increased anti-double stranded DNA antibody level ( J:266124 )

• at 6 months of age in un-immunized mice

hematopoietic system

increased germinal center B cell number ( J:266124 )

• minimal in young un-immunized mice on GL7+PNA+, which is further exacerbated with age

• at 6 months of age in un-immunized mice

• in young mice immunized with sheep red blood cells

increased plasma cell number ( J:266124 )

• in young mice immunized with sheep red blood cells

increased T follicular helper cell number ( J:266124 )

• at 6 months of age in un-immunized mice

• in young mice immunized with sheep red blood cells

increased IgG level ( J:266124 )

• SRBC-specific in young mice immunized with sheep red blood cells (SRBC)

increased IgG1 level ( J:266124 )

• following immunization with 4-hydroxy-3-nitrophenyl linked to Keyhole Limpet Hemocyanin (KLH) (NP-KLH) in alum

Allelic Composition	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(CD2-icre)4Kio/0
Genetic Background	involves: C57BL/6 * C57BL/10 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir146^tm1.1Lfl mutation (1 available); any Mir146 mutation (9 available)
Tg(CD2-icre)4Kio mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased germinal center B cell number ( J:266124 )

• following immunization with sheep red blood cells similar to in B cell conditional knock-outs

increased T follicular helper cell number ( J:266124 )

• following immunization with sheep red blood cells

hematopoietic system

increased germinal center B cell number ( J:266124 )

• following immunization with sheep red blood cells similar to in B cell conditional knock-outs

increased T follicular helper cell number ( J:266124 )

• following immunization with sheep red blood cells

Allelic Composition	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir146^tm1.1Lfl mutation (1 available); any Mir146 mutation (9 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:266124 )

N	• following immunization with sheep red blood cells, mice exhibit a wild-type response in elevation of germinal center B cells and T follicular helper cells

Allelic Composition	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Mir146b^tm1.1Lfl/Mir146b^tm1.1Lfl Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir146b^tm1.1Lfl mutation (1 available); any Mir146b mutation (2 available)
Mir146^tm1.1Lfl mutation (1 available); any Mir146 mutation (9 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased germinal center B cell number ( J:266124 )

• in young unimmunized mice with a further increase in mice immunized with sheep red blood cells

increased T follicular helper cell number ( J:266124 )

• in young unimmunized mice with a further increase in mice immunized with sheep red blood cells

increased IgG level ( J:266124 )

• in mice immunized with sheep red blood cells

hematopoietic system

increased germinal center B cell number ( J:266124 )

• in young unimmunized mice with a further increase in mice immunized with sheep red blood cells

increased T follicular helper cell number ( J:266124 )

• in young unimmunized mice with a further increase in mice immunized with sheep red blood cells

increased IgG level ( J:266124 )

• in mice immunized with sheep red blood cells

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