About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir146btm1.1Lfl
targeted mutation 1.1, Li-Fan Lu
MGI:6359886
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mir146btm1.1Lfl/Mir146btm1.1Lfl
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:6360067
cn2
 		Mir146tm1.1Lfl/Mir146tm1.1Lfl
Mir146btm1.1Lfl/Mir146btm1.1Lfl
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:6360068


Genotype
MGI:6360067
cn1
Allelic
Composition		 Mir146btm1.1Lfl/Mir146btm1.1Lfl
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir146btm1.1Lfl mutation (1 available); any Mir146b mutation (2 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:266124 )
N
• following immunization with sheep red blood cells, mice exhibit a wild-type response in elevation of germinal center B cells and T follicular helper cells




Genotype
MGI:6360068
cn2
Allelic
Composition		 Mir146tm1.1Lfl/Mir146tm1.1Lfl
Mir146btm1.1Lfl/Mir146btm1.1Lfl
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir146btm1.1Lfl mutation (1 available); any Mir146b mutation (2 available)
Mir146tm1.1Lfl mutation (1 available); any Mir146 mutation (9 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased germinal center B cell number ( J:266124 )
• in young unimmunized mice with a further increase in mice immunized with sheep red blood cells
increased T follicular helper cell number ( J:266124 )
• in young unimmunized mice with a further increase in mice immunized with sheep red blood cells
increased IgG level ( J:266124 )
• in mice immunized with sheep red blood cells

hematopoietic system
increased germinal center B cell number ( J:266124 )
• in young unimmunized mice with a further increase in mice immunized with sheep red blood cells
increased T follicular helper cell number ( J:266124 )
• in young unimmunized mice with a further increase in mice immunized with sheep red blood cells
increased IgG level ( J:266124 )
• in mice immunized with sheep red blood cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory