Analysis Tools
mortality/aging
|
• no mice are recovered after E14.5
|
reproductive system
|
• fewer primordial germ cells in the gonadal ridge at E11.5
|
nervous system
|
• slightly at E10.5, more severe at E12.5
|
|
• with thin and disorganized brain wall
|
|
• slightly at E10.5, more severe at E12.5
|
|
• slightly at E10.5, more severe at E12.5
|
|
• at E11.5 and E12.5
|
liver/biliary system
|
• at E12.5
• however, hepatic cell apoptosis is normal
|
|
• ectopic expression of the cholangiocyte marker Sox9 beyond the area surrounding bile ducts
|
|
• marker staining indicates that hepatic progenitors differentiate into cholangiocytes at the cost of hepatocytes
|
small liver
(
J:276703
)
|
• at E12.5 and E14.5
• however, liver size is normal at E10.5
|
pale liver
(
J:276703
)
|
• in embryos
|
cardiovascular system
|
• in most mice
|
cellular
|
• in the telencephalic midline at E11.5
|
|
• in lateral telencephalons at E12.5
|
|
• fewer primordial germ cells in the gonadal ridge at E11.5
|
|
• in the embryonic brain
|
|
• at E12.5
• however, hepatic cell apoptosis is normal
|
hematopoietic system
|
• impaired
|
embryo
|
• impaired
|
endocrine/exocrine glands
|
• ectopic expression of the cholangiocyte marker Sox9 beyond the area surrounding bile ducts
|
