Phenotypes associated with this allele

• Allele Symbol: Pacsin2^tm1.1Cgn
• Allele Name: targeted mutation 1.1, University of Cologne
• Allele ID: MGI:6360215
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pacsin2^tm1.1Cgn/Pacsin2^tm1.1Cgn	involves: BALB/cJ * C57BL/6	MGI:6360216

Genotype
MGI:6360216

hm1

• Allelic Composition: Pacsin2^tm1.1Cgn/Pacsin2^tm1.1Cgn
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:276621 )

N • mice exhibit normal heart morphology, weight, and structure

abnormal fetal cardiomyocyte physiology ( J:276621 )

• increased 90 percent of depolarization (APD90) and Vmax of action potential in atrial cells at E15.5 fetal cardiomyocyte

• increased Vmax of action potential in ventricular cells at E15.5

• decreased pacemaker funny channel (If), as well as L-type Ca2+ channel (ICaL), and sodium channel (INa) at E15.5

abnormal impulse conducting system conduction ( J:276621 )

• increased atrioventricular conduction time at E15.5

homeostasis/metabolism

impaired exercise endurance ( J:276621 )

• reduced running endurance, distance and speed

nervous system

abnormal action potential ( J:276621 )

• increased 90 percent of depolarization (APD90) and Vmax of action potential in atrial cells at E15.5 fetal cardiomyocyte

• increased Vmax of action potential in ventricular cells at E15.5 fetal cardiomyocyte

behavior/neurological

impaired exercise endurance ( J:276621 )

• reduced running endurance, distance and speed