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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Znhit1tm1.1Nju
targeted mutation 1.1, Model Animal Research Center of Nanjing University
MGI:6360223
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Olfm4tm2.1(EGFP/cre/ERT2)Cle/Olfm4+
Znhit1tm1.1Nju/Znhit1tm1.1Nju 		involves: 129P2/OlaHsd * C57BL/6 MGI:6360246
cn2
 		Znhit1tm1.1Nju/Znhit1tm1.1Nju
Tg(Vil1-cre)20Syr/0 		involves: C57BL/6 * DBA/2 MGI:6360245


Genotype
MGI:6360246
cn1
Allelic
Composition		 Olfm4tm2.1(EGFP/cre/ERT2)Cle/Olfm4+
Znhit1tm1.1Nju/Znhit1tm1.1Nju
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olfm4tm2.1(EGFP/cre/ERT2)Cle mutation (0 available); any Olfm4 mutation (30 available)
Znhit1tm1.1Nju mutation (0 available); any Znhit1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:276456 )
• all mice die by 18 days post tamoxifen treatment

digestive/alimentary system
abnormal intestine development ( J:276456 )
• postnatal depletion of intestinal stem cells in tamoxifen-treated mice
• however, embryonic development of Lgr5+ progenitor cells is normal




Genotype
MGI:6360245
cn2
Allelic
Composition		 Znhit1tm1.1Nju/Znhit1tm1.1Nju
Tg(Vil1-cre)20Syr/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)20Syr mutation (4 available)
Znhit1tm1.1Nju mutation (0 available); any Znhit1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:276456 )
• some mice die following the first week after birth

digestive/alimentary system
abnormal crypts of Lieberkuhn morphology ( J:276456 )
• enlarged postnatally that fail to form intestinal organoids in vitro
• however, embryonic intestinal development is normal

growth/size/body
decreased body weight ( J:276456 )
• from P5 through P30

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:276456 )
• enlarged postnatally that fail to form intestinal organoids in vitro
• however, embryonic intestinal development is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory