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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ndrg3em1Qshi
endonuclease-mediated mutation 1, Qinghua Shi
MGI:6360448
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ndrg3em1Qshi/Ndrg3em1Qshi C57BL/6-Ndrg3em1Qshi MGI:6360457
ht2
 		Ndrg3em1Qshi/Ndrg3+ C57BL/6-Ndrg3em1Qshi MGI:6360458


Genotype
MGI:6360457
hm1
Allelic
Composition		 Ndrg3em1Qshi/Ndrg3em1Qshi
Genetic
Background		 C57BL/6-Ndrg3em1Qshi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndrg3em1Qshi mutation (0 available); any Ndrg3 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:275135 )
• no mice are recovered from breeding heterozygotes with no mice present at E5.5




Genotype
MGI:6360458
ht2
Allelic
Composition		 Ndrg3em1Qshi/Ndrg3+
Genetic
Background		 C57BL/6-Ndrg3em1Qshi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndrg3em1Qshi mutation (0 available); any Ndrg3 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male meiosis ( J:275135 )
• at 18 dpp, spermatocytes remain at leptotene or zygotene-like stages compared with wild-type cells that progress to late pachytene
• reduced meiosis I and II at 8 weeks
reduced male fertility ( J:275135 )
• with fewer pups produced per litter

cellular
abnormal male meiosis ( J:275135 )
• at 18 dpp, spermatocytes remain at leptotene or zygotene-like stages compared with wild-type cells that progress to late pachytene
• reduced meiosis I and II at 8 weeks
abnormal double-strand DNA break repair ( J:275135 )
• during meiosis in spermatocytes

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:275135 )
• during meiosis in spermatocytes

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory