Phenotypes associated with this allele

• Allele Symbol: Ykt6^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6360693
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ykt6^em1(IMPC)J/Ykt6^em1(IMPC)J	C57BL/6NJ-Ykt6^em1(IMPC)J/Mmjax	MGI:6493200
ht2	Ykt6^em1(IMPC)J/Ykt6^+	C57BL/6NJ-Ykt6^em1(IMPC)J/Mmjax	MGI:6696973

Genotype
MGI:6493200

hm1

• Allelic Composition: Ykt6^em1(IMPC)J/Ykt6^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Ykt6^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Ykt6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ykt6^em1(IMPC)J/Ykt6^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts fail to hatch from the zona pellucida and are dead after 72hr in vitro outgrowth culture.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro outgrowth assays show that blastocysts fail to hatch from the zona pellucida and are dead after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• although early blastocysts are present in expected Mendelian ratios at E3.5, no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

Genotype
MGI:6696973

ht2

• Allelic Composition: Ykt6^em1(IMPC)J/Ykt6⁺
• Genetic Background: C57BL/6NJ-Ykt6^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Ykt6

behavior/neurological

increased exploration in new environment ( J:211773 )

♀

IMPC - JAX

hematopoietic system

decreased leukocyte cell number ( J:211773 )

♀

IMPC - JAX

immune system

decreased leukocyte cell number ( J:211773 )

♀

IMPC - JAX